Al-Badawi Saifaldeen, Ahmed Nada, Akber Mohammed
Internal Medicine, Birmingham Heartlands Hospital, Birmingham, GBR.
Dermatology, Lincoln County Hospital, Lincoln, GBR.
Cureus. 2023 Sep 25;15(9):e45965. doi: 10.7759/cureus.45965. eCollection 2023 Sep.
Erythroderma is a general term used to describe severe, intense skin inflammation. The condition is also known as exfoliative dermatitis when it is associated with exfoliation. Erythroderma has many causes, such as adverse drug eruption, dermatitis, psoriasis, pityriasis rubra pilaris, immunobullous disease, cutaneous T-cell lymphoma (Sézary syndrome), underlying systemic malignancy, graft versus host disease, and HIV infection. Many medications can cause erythroderma, including antibiotics, antiepileptics, angiotensin-converting enzyme (ACE) inhibitors, and sulfonamides. Here, we report a rare case of erythroderma secondary to gliclazide, an oral antidiabetic. This presentation is rare, as we found only one case report of gliclazide causing erythroderma in the literature. Erythroderma is considered a medical emergency requiring immediate diagnosis and prompt management; therefore, early intervention should start on suspicion without waiting for dermatologist confirmation, as this will significantly reduce the mortality and morbidity of this potentially life-threatening emergency.
红皮病是一个用于描述严重、剧烈皮肤炎症的通用术语。当与脱屑相关时，该病症也被称为剥脱性皮炎。红皮病有多种病因，如药物不良反应、皮炎、银屑病、毛发红糠疹、免疫性大疱性疾病、皮肤T细胞淋巴瘤（塞扎里综合征）、潜在的系统性恶性肿瘤、移植物抗宿主病以及HIV感染。许多药物可导致红皮病，包括抗生素、抗癫痫药、血管紧张素转换酶（ACE）抑制剂和磺胺类药物。在此，我们报告一例罕见的由口服降糖药格列齐特继发的红皮病病例。这种表现很罕见，因为我们在文献中仅发现一例关于格列齐特导致红皮病的病例报告。红皮病被视为一种需要立即诊断和迅速处理的医疗急症；因此，一旦怀疑应立即开始早期干预，无需等待皮肤科医生确认，因为这将显著降低这种潜在危及生命急症的死亡率和发病率。
