Dai Xinlun, Du Yangyang, Li Yumei, Yan Fei
Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China.
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China.
Mater Today Bio. 2023 Sep 16;23:100796. doi: 10.1016/j.mtbio.2023.100796. eCollection 2023 Dec.
Burgeoning is an evolution from conventional photodynamic therapy (PDT). Thus, sonodynamic therapy (SDT) regulated by nanoparticles (NPs) possesses multiple advantages, including stronger penetration ability, better biological safety, and not reactive oxygen species (ROS)-dependent tumor-killing effect. However, the limitation to tumor inhibition instead of shrinkage and the incapability of eliminating metastatic tumors hinder the clinical potential for SDT. Fortunately, immune checkpoint blockade (ICB) can revive immunological function and induce a long-term immune memory against tumor rechallenges. Hence, synergizing NPs-based SDT with ICB can provide a promising therapeutic outcome for solid tumors. Herein, we briefly reviewed the progress in NPs-based SDT and ICB therapy. We highlighted the synergistic anti-tumor mechanisms and summarized the representative preclinical trials on SDT-assisted immunotherapy. Compared to other reviews, we provided comprehensive and unique perspectives on the innovative sonosensitizers in each trial. Moreover, we also discussed the current challenges and future corresponding solutions.
新兴技术是从传统光动力疗法（PDT）发展而来的。因此，由纳米颗粒（NPs）调控的声动力疗法（SDT）具有多种优势，包括更强的穿透能力、更好的生物安全性以及不依赖活性氧（ROS）的肿瘤杀伤作用。然而，肿瘤抑制而非缩小的局限性以及无法消除转移性肿瘤阻碍了SDT的临床应用潜力。幸运的是，免疫检查点阻断（ICB）可以恢复免疫功能并诱导针对肿瘤再激发的长期免疫记忆。因此，将基于NPs的SDT与ICB协同使用可为实体瘤提供有前景的治疗效果。在此，我们简要回顾了基于NPs的SDT和ICB治疗的进展。我们强调了协同抗肿瘤机制，并总结了SDT辅助免疫治疗的代表性临床前试验。与其他综述相比，我们对每个试验中的创新型声敏剂提供了全面且独特的观点。此外，我们还讨论了当前的挑战及未来相应的解决方案。
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