State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Colleges of Materials Science and Engineering, Donghua University, Shanghai 201620, China.
Biomater Sci. 2023 Jun 27;11(13):4452-4470. doi: 10.1039/d3bm00556a.
In recent years, sonodynamic therapy (SDT) has emerged as a promising approach in biomedicine, due to its low toxicity, non-invasiveness, and deep tissue penetration for effective treatment of deep tumors. SDT utilizes ultrasound to irradiate sonosensitizers accumulated in tumors to generate reactive oxygen species (ROS), which can kill tumors by inducing apoptosis or necrosis in tumor cells. Developing safe and efficient sonosensitizers is a top priority in SDT. Recently reported sonosensitizers can be divided into three basic categories: organic, inorganic, and organic-inorganic hybrid sonosensitizers. Among these, metal-organic frameworks (MOFs) are a promising class of hybrid sonosensitizers due to their advantages of the linker-to-metal charge transfer mechanism for rapid ROS generation and the porous structure to eliminate self-quenching to increase the ROS generation efficiency. Moreover, MOF-based sonosensitizers can be combined with other therapies due to their large specific surface area, high porosity, and easy modification, which can increase the therapeutic efficacy through various synergistic effects. This review focuses on the latest progress in MOF-based sonosensitizers, strategies to improve the therapeutic effect, and the use of MOF-based sonosensitizers as multifunctional platforms for combination therapies emphasizing on increased therapeutic efficacy. Additionally, the challenges of MOF-based sonosensitizers from a clinical perspective are discussed.
近年来，声动力学疗法（SDT）作为一种有前途的生物医学方法出现，因为它具有低毒性、非侵入性和深组织穿透性，可有效治疗深部肿瘤。SDT 利用超声波照射积聚在肿瘤中的声敏剂以产生活性氧物种（ROS），通过诱导肿瘤细胞凋亡或坏死来杀死肿瘤。开发安全有效的声敏剂是 SDT 的首要任务。最近报道的声敏剂可分为三类：有机、无机和有机-无机杂化声敏剂。在这些声敏剂中，金属-有机骨架（MOFs）是一种很有前途的杂化声敏剂，因为其具有配体-金属电荷转移机制的优点，可以快速产生 ROS，以及多孔结构可以消除自猝灭，从而提高 ROS 生成效率。此外，由于 MOF 具有大的比表面积、高孔隙率和易于修饰的特点，基于 MOF 的声敏剂可以与其他疗法结合使用，通过各种协同作用提高治疗效果。本文重点介绍了基于 MOF 的声敏剂的最新进展、提高治疗效果的策略以及将基于 MOF 的声敏剂用作强调提高治疗效果的联合治疗的多功能平台。此外，还讨论了从临床角度来看基于 MOF 的声敏剂的挑战。
