Allergy Unit "D. Kalogeromitros", 2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, ATTIKON University General Hospital, Athens, Greece.
Allergy and Clinical Immunology Unit, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece 3 StArtBioP.C., Molecular Allergy Diagnostics, Athens, Greece.
Iran J Allergy Asthma Immunol. 2023 Sep 3;22(4):409-412. doi: 10.18502/ijaai.v22i4.13615.
Polyethylene glycols (PEG) or macrogols are polymers of ethylene oxide widely used in drugs either as active substances or, more commonly, as excipients. We report a Caucasian 32-year-old woman with referred anaphylaxis almost instantly after oral intake of a macrogol-containing laxative. Despite an anaphylactic reaction, the patient showed negative results for both the skin test and specific IgE to monomer, while the basophil activation test and oral challenge were positive. The patient was later successfully vaccinated with a polysorbate 80-containing SARS-CoV-2 vaccine following an additional work-up. As a result, the inactive form of PEG cannot be fully diagnosed, and it is considered a "hidden" allergen. Allergens like polysorbates need special consideration due to their possible cross-reactivity by their specific derivatives.
聚乙二醇（PEG）或聚氧化乙烯是广泛用于药物的氧化乙烯聚合物，既可以作为活性物质，也可以更常见地作为赋形剂。我们报告了一例高加索 32 岁女性，在口服含有聚乙二醇的泻药后几乎立即出现过敏反应。尽管发生了过敏反应，但患者的皮肤试验和对单体的特异性 IgE 均为阴性，而嗜碱性粒细胞激活试验和口服挑战为阳性。在进一步检查后，该患者后来成功接种了一种含有聚山梨酯 80 的 SARS-CoV-2 疫苗。因此，PEG 的无活性形式不能被完全诊断，它被认为是一种“隐藏”过敏原。像聚山梨酯这样的过敏原需要特别考虑，因为它们的特定衍生物可能会发生交叉反应。
