Medical University of Lodz, Łódź, Poland (Department of Pediatrics and Allergy, Copernicus Memorial Hospital).
Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Environmental and Occupational Health Hazards).
Int J Occup Med Environ Health. 2023 Nov 27;36(5):575-586. doi: 10.13075/ijomeh.1896.02184. Epub 2023 Sep 27.
Bisphenols, endocrine disrupting chemicals, are widely used in daily life. Continued exposure during key developmental periods of life (pregnancy, infancy and early childhood) can contribute to adverse health consequences such as decreased lung function, wheezing/asthma, the occurrence of allergies or changes in immune system responses. The purpose of this review is to present the current state of knowledge on the effects of prenatal or postnatal exposure to bisphenol A (BPA), bisphenol S (BPS) and bisphenol F (BPF) on the development of allergic diseases in childhood. A com- prehensive and systematic search of PubMed, Scopus and Web of Science databases was conducted. The review is restricted to studies published since 2015, in English in peer-reviewed journals. Based on keywords, 2648 studies were identified and reviewed for eligibility. Finally, 8 epidemio- logical studies were found to be appropriate for inclusion in this publication. The data collected in this review suggests that there is an associa- tion between maternal exposure during pregnancy or childhood to BPA and the development of allergic diseases. Most studies reported positive relationships between BPA exposure and at least one of the types of allergic disease. The paucity of studies and the observed differences in findings regarding the association between prenatal/postnatal exposure to BPS and/or BPF do not allow firm conclusions to be drawn. Further research is needed to identify the vulnerable population and the mechanisms responsible for the development of undesirable health consequences. Int J Occup Med Environ Health. 2023;36(5):575-86.
双酚类物质，内分泌干扰化学物质，在日常生活中被广泛使用。在生命的关键发育期（妊娠、婴儿期和幼儿期）持续暴露，可能导致不良健康后果，如肺功能下降、喘息/哮喘、过敏发生或免疫系统反应改变。本综述的目的是介绍产前或产后暴露于双酚 A（BPA）、双酚 S（BPS）和双酚 F（BPF）对儿童期过敏性疾病发展的影响的现有知识状态。对 PubMed、Scopus 和 Web of Science 数据库进行了全面和系统的搜索。综述仅限于 2015 年以后发表的、在同行评审期刊上发表的英文研究。基于关键词，确定了 2648 项研究，并对其进行了资格审查。最后，发现 8 项流行病学研究适合纳入本出版物。本综述中收集的数据表明，母亲在怀孕期间或儿童期暴露于 BPA 与过敏性疾病的发展之间存在关联。大多数研究报告了 BPA 暴露与至少一种类型的过敏性疾病之间存在正相关关系。由于关于产前/产后暴露于 BPS 和/或 BPF 与过敏症之间的关联的研究很少，且观察到的结果存在差异，因此无法得出明确的结论。需要进一步研究以确定易受影响的人群和导致不良健康后果的机制。国际职业医学与环境卫生杂志。2023;36(5):575-86.
