Medical Scientific Educational Center, M. V. Lomonosov Moscow State University, Moscow, Russia.
P. A. Herzen Moscow Research Oncological Institute - Branch of National Medical Research Center of Radiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Bull Exp Biol Med. 2023 Aug;175(4):508-512. doi: 10.1007/s10517-023-05896-x. Epub 2023 Sep 28.
In 139 patients with verified gastric cancer, the infiltration of the postoperative material with CD8 cells was analyzed. Automated morphometric analysis of immunostained slides was performed separately in different specimen sites (tumor center, invasive edge, and peritumoral mucosa). The mean area of infiltrating CD8 cells in the tumor center and in the invasive edge was not predictive, while in the peritumoral mucosa it provided a new negative predictive factor (hazard ratio 2.10; confidence interval 0.87-4.92, Cox regression) reliably associated with the TNM stage (hazard ratio 1.91; confidence interval 0.91-4.61, Cox regression).
在 139 例经证实的胃癌患者中，分析了术后标本中 CD8 细胞的浸润情况。对免疫染色载玻片进行了自动形态计量分析，分别在不同的标本部位（肿瘤中心、浸润边缘和肿瘤周围黏膜）进行分析。肿瘤中心和浸润边缘浸润 CD8 细胞的平均面积没有预测性，而在肿瘤周围黏膜中，它提供了一个新的负预测因素（风险比 2.10；95%置信区间 0.87-4.92，Cox 回归），与 TNM 分期可靠相关（风险比 1.91；95%置信区间 0.91-4.61，Cox 回归）。
