Department of Endocrinology, Jinan Central Hospital, Shandong University, Jinan, China.
Department of Infectious Diseases, Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan, China.
J Diabetes Complications. 2023 Nov;37(11):108614. doi: 10.1016/j.jdiacomp.2023.108614. Epub 2023 Sep 25.
Asprosin, encoded by penultimate two exons (exon 65 and exon 66) of the gene Fibrillin 1 (FBN1), has been recently discovered to be a novel hormone secreted by white adipose tissues during fasting. The glucose metabolism disorders are often accompanied by increased asprosin level. Previous research suggests that asprosin may contribute to the development of diabetes by regulating glucose homeostasis, appetite, insulin secretion, and insulin sensitivity. In this review, we summarize the recent findings from studies on asprosin and its association with Type 2 diabetes mellitus, and discusses its mechanisms from various aspects, so as to provide clinical diagnosis and treatment ideas for T2DM.
阿普素林由原纤维蛋白 1 基因（FBN1）的倒数第二外显子（外显子 65 和外显子 66）编码，最近被发现是一种在禁食状态下由白色脂肪组织分泌的新型激素。葡萄糖代谢紊乱常伴有阿普素林水平升高。先前的研究表明，阿普素林可能通过调节葡萄糖稳态、食欲、胰岛素分泌和胰岛素敏感性来促进糖尿病的发展。在这篇综述中，我们总结了关于阿普素林及其与 2 型糖尿病的关系的研究的最新发现，并从各个方面讨论了其机制，以期为 T2DM 的临床诊断和治疗提供思路。
