一种新药布累迪宁对犬肾同种异体移植存活的有效性。
Effectiveness of a new drug, bredinin, on canine kidney allotransplant survival.
作者信息
Uchida H, Yokota K, Akiyama N, Masaki Y, Aso K, Okubo M, Okudaira M, Kato M, Kashiwagi N
出版信息
Transplant Proc. 1979 Mar;11(1):865-70.
PMID:377720
Abstract
BR has remarkable effectiveness on canine kidney allograft survival. Its effectiveness in suppression of the immune responses is dependent on the dosage. Atrophy of the spleen and the mesenteric lymph nodes is prominent in treated dogs. Septic complications are slight, with no reduction in the number of peripheral white blood cells. Erosive changes of the mucosa in the entire bowel are the major side effects of the drug treatment. Liver functional abnormality has not been observed.
摘要
BR对犬肾同种异体移植存活具有显著效果。其在抑制免疫反应方面的有效性取决于剂量。在接受治疗的犬中，脾脏和肠系膜淋巴结萎缩明显。脓毒症并发症轻微，外周血白细胞数量未减少。药物治疗的主要副作用是全肠道黏膜的糜烂性改变。未观察到肝功能异常。
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