脂质体FK506在肝移植和肾移植中的不同免疫抑制作用。
Different immunosuppressive effects of liposomal FK506 in liver and kidney transplantation.
作者信息
Ko S, Nakajima Y, Kanehiro H, Horikawa M, Yoshimura A, Kido K, Taki J, Aomatsu Y, Kin T, Yagura K, Ohyama T, Ohashi K, Yamada T, Nakano H
机构信息
First Department of Surgery, Nara Medical University, Kashihara, Japan.
出版信息
Transplant Proc. 1996 Apr;28(2):1066-8.
The efficacy of liposomal FK506 was compared between a canine liver transplantation model and a canine kidney transplantation model. The present study revealed that liposomal FK506 increased immunosuppressive efficacy of FK506 in liver transplantation but decreased in kidney transplantation. Because liposomal FK506 increased FK506 levels in the liver and spleen, and decreased FK506 levels in the kidney, it was suggested that enhanced immunosuppressive efficacy in liver transplantation should be attributed to the local immunosuppressive effects in the hepatic allograft rather than effective suppression of splenocyte activity.
在犬肝移植模型和犬肾移植模型之间比较了脂质体FK506的疗效。本研究表明，脂质体FK506在肝移植中提高了FK506的免疫抑制效果，但在肾移植中降低了其免疫抑制效果。由于脂质体FK506增加了肝脏和脾脏中FK506的水平，而降低了肾脏中FK506的水平，因此提示肝移植中免疫抑制效果增强应归因于肝同种异体移植物中的局部免疫抑制作用，而非对脾细胞活性的有效抑制。
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