Chen Xiaoyao, Kriebisch Brigitte A K, Bergmann Alexander M, Boekhoven Job
Department of Chemistry, School of Natural Sciences, Technical University of Munich Lichtenbergstrasse 4 85748 Garching bei München Germany
Chem Sci. 2023 Aug 22;14(37):10176-10183. doi: 10.1039/d3sc02062b. eCollection 2023 Sep 27.
Biology regulates the function and assembly of proteins through non-equilibrium reaction cycles. Reciprocally, the assembly of proteins can influence the reaction rates of these cycles. Such reciprocal coupling between assembly and reaction cycle is a prerequisite for behavior like dynamic instabilities, treadmilling, pattern formation, and oscillations between morphologies. While assemblies regulated by chemical reaction cycles gained traction, the concept of reciprocal coupling is under-explored. In this work, we provide two molecular design strategies to tweak the degree of reciprocal coupling between the assembly and reaction cycle. The strategies involve spacing the chemically active site away from the assembly or burying it into the assembly. We envision that design strategies facilitate the creation of reciprocally coupled and, by extension, dynamic supramolecular materials in the future.
生物学通过非平衡反应循环来调节蛋白质的功能和组装。反过来，蛋白质的组装也会影响这些循环的反应速率。组装与反应循环之间的这种相互耦合是动态不稳定性、踏车行为、图案形成以及形态间振荡等行为的先决条件。虽然由化学反应循环调节的组装受到了关注，但相互耦合的概念仍未得到充分探索。在这项工作中，我们提供了两种分子设计策略来调整组装与反应循环之间的相互耦合程度。这些策略包括将化学活性位点与组装部分隔开或使其埋入组装部分中。我们设想这些设计策略将有助于未来创建相互耦合的、进而动态的超分子材料。
