Yan Yunying, Hao Jianjun, Xie Fenfen, Han Fen, Jing Linhai, Han Pan
Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China.
J Org Chem. 2023 Oct 20;88(20):14640-14648. doi: 10.1021/acs.joc.3c01632. Epub 2023 Sep 29.
Magnesium-mediated reductive carboxylation of -QMs with CO via an Umpolung strategy has been developed, which can be used for the preparation of various aryl acetic acids. This protocol featured high atom economy, mild conditions, and operational simplicity. The creation of this Umpolung carboxylation of -QMs will unprecedentedly extend the application of -QMs to nucleophilic reagents.
通过极性翻转策略实现了镁介导的-QMs与CO的还原羧化反应，该反应可用于制备各种芳基乙酸。该方法具有高原子经济性、温和的反应条件和操作简便的特点。这种-QMs的极性翻转羧化反应的建立将前所未有的扩展-QMs作为亲核试剂的应用。
