Fang Fang, Xia Jie, Quan Siying, Chen Shanping, Deng Guo-Jun
Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education Hunan Province, Key Laboratory of Green Organic Synthesis and Application, College of Chemistry, Xiangtan University, Xiangtan 411105, P. R. China.
College of Materials and Chemical Engineering, Hunan City University, Yiyang 413000, P. R. China.
J Org Chem. 2023 Oct 20;88(20):14697-14707. doi: 10.1021/acs.joc.3c01700. Epub 2023 Sep 29.
A facile and practical approach for the preparation of substituted pyrimidines from ketones, NHOAc, and ,-dimethylformamide dimethyl acetal has been described. This NHI-promoted three-component tandem reaction affords a broad range of substituted pyrimidines in acceptable yields under metal- and solvent-free conditions. The present methodology features the advantages of simple and easily available starting materials, metal- and solvent-free conditions, a broad substrate scope with good functional group tolerance, and gram-scale synthesis.
