Altern Ther Health Med. 2024 Jan;30(1):111-115.
To explore the effects on cognitive function and survival time of whole-brain intensity-modulated radiotherapy using radiotherapy equipment to protect the hippocampus.
Thirty-six patients with brain metastases treated at Qianjiang Central Hospital were enrolled in this study from January 2019 to September 2022. The patients were randomly divided into 2 groups: 15 patients received hippocampal-protection whole-brain radiotherapy, and 21 patients received conventional whole-brain radiotherapy. The Montreal Cognitive Assessment was used to evaluate the cognitive function of patients before and 24 hours, 2 months, 6 months, and 12 months after radiotherapy. Cognitive dysfunction and survival time were compared between the 2 groups.
The overall mean differences in the Montreal Cognitive Assessment scores between the hippocampal-protection group and the conventional whole-brain radiotherapy group were statistically significant at 6 months (P = .006) and 12 months (P = .04) after radiotherapy. The median overall survival was 16 months (95% CI, 11.54-20.46) for the hippocampal-protection group and 14 months (95% CI, 12.9-15.21) for the conventional whole-brain radiotherapy group (P = .578). The median progression-free survival was 12 months (95% CI, 9.74-14.26) for the hippocampal-protection group and 9 months (95% CI, 6.60-11.44) for the conventional whole-brain radiotherapy group (P = .494).
Whole-brain radiotherapy for protecting the hippocampus can delay cognitive dysfunction in patients to some extent.
探索使用放射治疗设备保护海马的全脑强度调节放射治疗对认知功能和生存时间的影响。
本研究纳入 2019 年 1 月至 2022 年 9 月在潜江中心医院接受治疗的 36 例脑转移患者。将患者随机分为 2 组：15 例患者接受海马保护全脑放疗，21 例患者接受常规全脑放疗。使用蒙特利尔认知评估量表评估患者放疗前和放疗后 24 小时、2 个月、6 个月和 12 个月的认知功能。比较两组患者的认知功能障碍和生存时间。
海马保护组和常规全脑放疗组患者在放疗后 6 个月（P =.006）和 12 个月（P =.04）时蒙特利尔认知评估量表评分的总体平均差异具有统计学意义。海马保护组的中位总生存期为 16 个月（95%CI，11.54-20.46），常规全脑放疗组为 14 个月（95%CI，12.9-15.21）（P =.578）。海马保护组的中位无进展生存期为 12 个月（95%CI，9.74-14.26），常规全脑放疗组为 9 个月（95%CI，6.60-11.44）（P =.494）。
保护海马的全脑放疗在一定程度上可以延缓患者的认知功能障碍。
