State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
Upper Airways Research Laboratory, Department of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Sci Adv. 2023 Sep 29;9(39):eadh1991. doi: 10.1126/sciadv.adh1991.
E4F transcription factor 1 (E4F1), a member of the GLI-Kruppel family of zinc finger proteins, is now widely recognized as a transcription factor. It plays a critical role in regulating various cell processes, including cell growth, proliferation, differentiation, apoptosis and necrosis, DNA damage response, and cell metabolism. These processes involve intricate molecular regulatory networks, making E4F1 an important mediator in cell biology. Moreover, E4F1 has also been implicated in the pathogenesis of a range of human diseases. In this review, we provide an overview of the major advances in E4F1 research, from its first report to the present, including studies on its protein domains, molecular mechanisms of transcriptional regulation and biological functions, and implications for human diseases. We also address unresolved questions and potential research directions in this field. This review provides insights into the essential roles of E4F1 in human health and disease and may pave the way for facilitating E4F1 from basic research to clinical applications.
E4F 转录因子 1（E4F1）是 GLI-Kruppel 家族锌指蛋白中的一员，现已被广泛认为是一种转录因子。它在调节各种细胞过程中起着关键作用，包括细胞生长、增殖、分化、凋亡和坏死、DNA 损伤反应以及细胞代谢。这些过程涉及复杂的分子调控网络，使 E4F1 成为细胞生物学中的重要介体。此外，E4F1 还与多种人类疾病的发病机制有关。在这篇综述中，我们概述了 E4F1 研究的主要进展，从最初的报道到现在，包括对其蛋白质结构域、转录调控的分子机制和生物学功能以及对人类疾病的影响的研究。我们还讨论了该领域尚未解决的问题和潜在的研究方向。本文综述提供了 E4F1 在人类健康和疾病中的重要作用的见解，并可能为促进 E4F1 从基础研究到临床应用铺平道路。
