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乳腺癌骨转移病灶的巨观形态计量分析：对人类鉴识之贡献。

Macromorphometric Analysis of Metastatic Lesions in Bones due to Breast Cancer: Contribution to Human Identification.

机构信息

Faculty of Odontology of the University of Pernambuco (FOP/UPE), Recife, Brazil.

Master's Program in Forensic Sciences, Center for Forensic Anthropology Studies of the Faculty of Odontology of the University of Pernambuco (CEAF/FOP/UPE), Recife, Brazil.

出版信息

Asian Pac J Cancer Prev. 2023 Sep 1;24(9):3087-3097. doi: 10.31557/APJCP.2023.24.9.3087.

DOI:10.31557/APJCP.2023.24.9.3087
PMID:37774060
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10762763/
Abstract

OBJECTIVE

This study aimed to report the metastatic lesions observed in identified skeletons whose deaths were caused by breast cancer complications to provide information and evidence that can be used in cases of human identification forensics.

METHODS

The research was conducted at the Centre for Forensic Anthropology Studies of the Faculty of Odontology of the University of Pernambuco (CEAF/FOP/UPE), Recife, Brazil. The data bank of the CEAF/FOP/UPE was searched for skeletons with the cause of death reported as due to breast cancer, resulting in five cases. The skeletons were arranged in anatomical positions and macroscopically inspected to register, describe and measure the lesions present to establish the macroscopic patterns of bone destruction caused by breast cancer.

RESULT

Of the five skeletons, two presented metastatic lesions. In the first, lesions were observed in a disseminated form, affecting almost all bones. The lesions were predominantly osteolytic and ellipsoid-shaped; however, mixed and circular lesions were also found. The second skeleton presented four lesions of mixed characteristics. The finding of bone lesions in the macroscopic analysis of skeletons may reveal a more advanced stage of the neoplasm, as well as its dissemination in areas little rich in hematopoietic tissue, such as the diaphyses of long bones, a situation widely observed in the first reported case.

CONCLUSION

Besides providing more excellent knowledge of their macroscopic presentation, bone metastatic lesions may act as an individualizing factor in human identification cases, narrowing the sample of possible victims.

摘要

目的

本研究旨在报告因乳腺癌并发症而死亡的已识别骨骼中观察到的转移病变，为人类身份识别法医提供可用于鉴定的信息和证据。

方法

该研究在巴西累西腓伯南布哥大学牙科学院法医人类学研究中心（CEAF/FOP/UPE）进行。在 CEAF/FOP/UPE 的数据库中搜索死因报告为乳腺癌的骨骼，共发现五例。将骨骼按解剖位置排列并进行宏观检查，以记录、描述和测量存在的病变，确定乳腺癌引起的骨破坏的宏观模式。

结果

在这五具骨骼中，有两具呈现出转移性病变。第一具骨骼中，病变呈弥漫性分布，几乎影响所有骨骼。病变主要为溶骨性和椭圆形；然而，也发现了混合性和圆形病变。第二具骨骼呈现出四种混合特征的病变。在骨骼的宏观分析中发现骨病变可能表明肿瘤处于更晚期，并且在造血组织较少的区域（如长骨骨干）扩散，这种情况在第一个报告病例中广泛观察到。

结论

除了提供对其宏观表现的更深入了解外，骨骼转移病变还可以作为人类识别案例中的个体特征，缩小可能受害者的样本范围。

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