Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, China.
Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City and Southwest University, College of Agronomy and Biotechnology, Southwest University, Chongqing, China; Department of Biochemistry, Women Medical and Dental College, Khyber Medical University, Abbottabad, Pakistan.
Curr Probl Cardiol. 2024 Jan;49(1 Pt B):102112. doi: 10.1016/j.cpcardiol.2023.102112. Epub 2023 Sep 27.
Cardiovascular disease is the leading cause of death, medical complications, and healthcare costs. Although recent advances have been in treating cardiovascular disorders linked with a reduced ejection fraction, acutely decompensate cardiac failure remains a significant medical problem. The transient receptor potential cation channel (TRPC6) family responds to neurohormonal and mechanical stress, playing critical roles in cardiovascular diseases. Therefore, TRP C6 channels have great promise as therapeutic targets. Numerous studies have investigated the roles of TRP C6 channels in pain neurons, highlighting their significance in cardiovascular research. The TRPC6 protein exhibits a broad distribution in various organs and tissues, including the brain, nerves, heart, blood vessels, lungs, kidneys, gastrointestinal tract, and other bodily structures. Its activation can be triggered by alterations in osmotic pressure, mechanical stimulation, and diacylglycerol. Consequently, TRPC6 plays a significant role in the pathophysiological mechanisms underlying diverse diseases within living organisms. A recent study has indicated a strong correlation between the disorder known as TRPC6 and the development of cardiovascular diseases. Consequently, investigations into the association between TRPC6 and cardiovascular diseases have gained significant attention in the scientific community. This review explores the most recent developments in the recognition and characterization of TRPC6. Additionally, it considers the field's prospects while examining how TRPC6 might be altered and its clinical applications.
心血管疾病是死亡、医疗并发症和医疗保健费用的主要原因。尽管最近在治疗与射血分数降低相关的心血管疾病方面取得了进展，但急性失代偿性心力衰竭仍然是一个重大的医疗问题。瞬时受体电位阳离子通道（TRPC6）家族对神经激素和机械应激作出反应，在心血管疾病中发挥着关键作用。因此，TRP C6 通道作为治疗靶点具有很大的潜力。许多研究已经研究了 TRP C6 通道在疼痛神经元中的作用，强调了它们在心血管研究中的重要性。TRPC6 蛋白在各种器官和组织中广泛分布，包括大脑、神经、心脏、血管、肺、肾脏、胃肠道和其他身体结构。其激活可以通过渗透压变化、机械刺激和二酰基甘油触发。因此，TRPC6 在生物体中多种疾病的病理生理机制中起着重要作用。最近的一项研究表明，TRPC6 紊乱与心血管疾病的发展之间存在很强的相关性。因此，TRPC6 与心血管疾病之间的关联研究在科学界引起了广泛关注。本综述探讨了 TRPC6 识别和特征描述的最新进展。此外，在研究 TRPC6 如何改变及其临床应用的同时，还考虑了该领域的前景。
