Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Brain Res. 2023 Dec 1;1820:148605. doi: 10.1016/j.brainres.2023.148605. Epub 2023 Sep 27.
To explore potential mechanisms of cognitive changes in patients with anti-NMDAR encephalitis (ANMDARE) from intramodule and intermodule effects of brain functional networks.
Resting-state functional MRI(rs-fMRI) imaging data was collected from 30 ANMDARE and 30 healthy controls (HCs). A brain functional matrix was constructed, and sparsity was established by module similarity. For both groups, changes in functional connectivity (FC) within and between modules was calculated, and whole-brain functional topology was analyzed. Finally, the association of brain functional with cognitive function in ANMDARE was further analyzed.
Compared to HCs, ANMDARE had enhanced connectivity within the modules that included the occipito-parietal-temporal and parahippocampal gyri. ANMDARE had significantly higher participation coefficients (PC) in the right inferior frontal gyrus than HCs and significantly lower PC in the left superior parietal lobule, left caudate nucleus, and right putamen. No statistically significant differences in global topological properties were found between the two groups. No correlations were found between functional and structural brain indicators and the Cognitive Assessment Scale and the Emotional Deficit Scale.
Patients with ANMDARE are manifested by enhanced intramodular FC and intermodular connectivity changes in the brain. This may help to understand the pathophysiological mechanisms of the disease from a global perspective.
从脑功能网络的模块内和模块间效应探讨抗 N-甲基-D-天冬氨酸受体脑炎（anti-NMDAR encephalitis，ANMDARE）患者认知变化的潜在机制。
收集 30 例 ANMDARE 患者和 30 例健康对照者（healthy controls，HCs）的静息态功能磁共振成像（resting-state functional MRI，rs-fMRI）数据。构建脑功能矩阵，通过模块相似性确定稀疏性。对两组患者，分别计算模块内和模块间功能连接（functional connectivity，FC）的变化，并分析全脑功能拓扑。最后，进一步分析 ANMDARE 患者脑功能与认知功能的相关性。
与 HCs 相比，ANMDARE 患者的枕顶颞叶和海马旁回等模块内的 FC 增强。与 HCs 相比，ANMDARE 患者右侧额下回的参与系数（participation coefficient，PC）显著升高，左侧顶上小叶、左侧尾状核和右侧壳核的 PC 显著降低。两组间的全局拓扑性质无统计学差异。脑功能和结构指标与认知评估量表和情绪缺陷量表之间无相关性。
ANMDARE 患者表现为脑内增强的模块内 FC 和模块间连接变化，这可能有助于从全局角度理解疾病的病理生理机制。
