Innovations in Small-Animal PET Instrumentation.

Biomedical research has long relied on small-animal studies to elucidate disease process and develop new medical treatments. The introduction of in vivo functional imaging technology, such as PET, has allowed investigators to peer inside their subjects and follow disease progression longitudinally as well as improve understanding of normal biological processes. Recent developments in CRISPR, immuno-PET, and high-resolution in vivo imaging have only increased the importance of small-animal, or preclinical, PET imaging. Other drivers of preclinical PET innovation include new combinations of imaging technologies, such as PET/MR imaging, which require changes to PET hardware.