Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Trends Biochem Sci. 2023 Dec;48(12):1012-1013. doi: 10.1016/j.tibs.2023.09.007. Epub 2023 Sep 27.
A recent study by Fenstermaker et al. in Nature describes how transcriptionally active RNA polymerase II (Pol II) clings to the genomic tightrope during the passage of the replication fork and rapidly resumes transcription of immature RNA from both strands of nascent DNA, facilitated by protein-protein interactions between the replication and transcription machineries.
芬斯特马克等人最近在《自然》杂志上的一项研究描述了转录活跃的 RNA 聚合酶 II（Pol II）在复制叉通过时如何紧贴基因组的细索，并通过复制和转录机制之间的蛋白质-蛋白质相互作用，从新生 DNA 的两条链上迅速恢复不成熟 RNA 的转录。
