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机械性肠道准备不支持择期结直肠手术吻合:一项回顾性研究。

Mechanical bowel preparations not supported in elective colo-rectal surgeries with anastomosis: A retrospective study.

机构信息

University of North Carolina, Chapel Hill, NC, USA.

Department of General Surgery, Essentia Health Duluth, MN, USA.

出版信息

Am Surg. 2023 Nov;89(11):4246-4251. doi: 10.1177/00031348231204911. Epub 2023 Sep 30.

Abstract

OBJECTIVE

To analyze the risk and benefit of bowel preparations in elective colo-rectal surgery.

BACKGROUND

Mechanical bowel preparations (MBPs) have been popularized in colo-rectal surgery since studies in the 1970s, but recent data has called their use into question and examined complication rates between patients with and without bowel preparations.

METHODS

A retrospective case-review was performed consisting of 1237 elective colo-rectal surgeries performed by two surgeons between 2008 and 2021. Patients received either a MBP, a mechanical bowel preparation with oral antibiotics (OAMBP), oral antibiotics alone (OA), or no bowel preparation; some patients across all categories received an enema.

RESULTS

Bowel preparations combined (MBP and OAMBP) totaled 436 patients and showed no statistically significant difference ( > .05) in primary outcomes of wound infection and anastomotic leak when compared to the 636 patients without a bowel preparation and 165 patients with OA. The analysis controlled for comorbidities and presence of enema. Of secondary outcomes, urinary tract infections (UTIs) were significantly more common in patients who received a bowel preparation ( = .047). All other outcomes showed no significant difference between groups, including complications on day of surgery; complications, readmission with and without surgery, and ileus formation within 30 days of surgery; sepsis; pneumonia; and length of stay (LOS). The presence of enemas did not have a statistically significant effect on outcomes.

CONCLUSIONS

This study's data does not support the routine use of MBPs in elective colo-rectal surgery and draws into further question whether MBPs should remain standard of care.

摘要

目的

分析择期结肠直肠手术中肠道准备的风险和获益。

背景

自 20 世纪 70 年代的研究以来,机械性肠道准备(MBP)已在结肠直肠手术中得到普及,但最近的数据对其使用提出了质疑,并检查了有和没有肠道准备的患者之间的并发症发生率。

方法

对两位外科医生在 2008 年至 2021 年间进行的 1237 例择期结肠直肠手术进行了回顾性病例回顾。患者接受了 MBP、口服抗生素的机械性肠道准备(OAMBP)、单独口服抗生素(OA)或没有肠道准备;一些患者在所有类别中都接受了灌肠。

结果

肠道准备(MBP 和 OAMBP)总计 436 例,与未进行肠道准备的 636 例和单独使用 OA 的 165 例患者相比,在伤口感染和吻合口漏的主要结局方面无统计学显著差异(>.05)。分析控制了合并症和灌肠的存在。在次要结局中,接受肠道准备的患者尿路感染(UTI)明显更常见(=.047)。所有其他结局在组间均无显著差异,包括手术当天的并发症;有或无手术的再入院,以及术后 30 天内的肠梗阻形成;脓毒症;肺炎;和住院时间(LOS)。灌肠的存在对结果没有统计学显著影响。

结论

本研究的数据不支持在择期结肠直肠手术中常规使用 MBP,并进一步质疑 MBP 是否应继续作为标准护理。

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