Bednarski R M, Majors L J
Am J Vet Res. 1986 Oct;47(10):2122-5.
Epinephrine-induced arrhythmias were studied in 4 cats (group A), using a 4 X 4 Latin square design. Each cat was anesthetized 4 times, 1 week apart, with halothane (1.5% end expired), isoflurane (2.0% end expired), and halothane or isoflurane preceded by ketamine administered IM (8.8 mg/kg). Lead II of the ECG and femoral artery pressure were recorded. Epinephrine was infused in progressively doubled rates (initial rate = 0.125 micrograms/kg/min) for a maximum of 2.5 minutes or until at least 4 ventricular premature depolarizations occurred within 15 s of each other. The arrhythmogenic dose of epinephrine (ADE; micrograms/kg) was calculated as the product of infusion rate and time to arrhythmia. The ADE (means +/- SD) during anesthesia with halothane alone and with ketamine-halothane anesthesia were 1.33 +/- 0.65 and 1.37 +/- 0.59 micrograms/kg, respectively; during anesthesia with isoflurane alone and ketamine-isoflurane anesthesia, the ADE were 9.34 +/- 1.29 and 16.16 +/- 3.63 micrograms/kg, respectively. The ADE was significantly greater (P less than 0.05) during isoflurane anesthesia and ketamine-isoflurane anesthesia than during halothane anesthesia. The percentages of change in systolic blood pressure (means +/- SD) at the ADE during halothane, ketamine-halothane, isoflurane, and ketamine-isoflurane were 31 +/- 34, 41 +/- 17, 127 +/- 27, and 148 +/- 57, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
采用4×4拉丁方设计，对4只猫（A组）进行了肾上腺素诱发心律失常的研究。每只猫每隔1周用氟烷（呼气末浓度1.5%）、异氟烷（呼气末浓度2.0%）麻醉4次，以及在肌注氯胺酮（8.8mg/kg）后用氟烷或异氟烷麻醉。记录心电图II导联和股动脉血压。以逐渐加倍的速率（初始速率=0.125μg/kg/min）输注肾上腺素，最长持续2.5分钟，或直至每15秒内至少发生4次室性早搏。肾上腺素致心律失常剂量（ADE；μg/kg）通过输注速率与心律失常发生时间的乘积计算得出。单独使用氟烷麻醉和氯胺酮-氟烷麻醉期间的ADE（均值±标准差）分别为1.33±0.65和1.37±0.59μg/kg；单独使用异氟烷麻醉和氯胺酮-异氟烷麻醉期间，ADE分别为9.34±1.29和16.16±3.63μg/kg。异氟烷麻醉和氯胺酮-异氟烷麻醉期间的ADE显著高于氟烷麻醉期间（P<0.05）。氟烷、氯胺酮-氟烷、异氟烷和氯胺酮-异氟烷麻醉下达到ADE时收缩压的变化百分比（均值±标准差）分别为31±34、41±17、127±27和148±57。（摘要截断于250字）
