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一例高毒力 K1-ST23 型肺炎克雷伯菌心内膜炎及多发部位脓肿致乳头肌断裂。

A case of hypervirulent K1-ST23 Klebsiella pneumoniae endocarditis and papillary muscle rupture secondary to multiple site abscesses.

机构信息

Department of Infectious Diseases, The University of Tokyo Hospital, Tokyo, Japan.

Department of Infectious Diseases, The University of Tokyo Hospital, Tokyo, Japan.

出版信息

J Infect Chemother. 2024 Feb;30(2):154-158. doi: 10.1016/j.jiac.2023.09.028. Epub 2023 Sep 29.

Abstract

Hypervirulent Klebsiella pneumoniae (hvKP) causes multisite infections and abscesses. However, endocarditis is a rare presentation of hvKP infection. Herein, we report a case of K. pneumoniae native valve infective endocarditis secondary to community-acquired liver and prostate abscesses. The patient developed papillary muscle rupture, leading to mitral regurgitation, and underwent emergent mitral valve replacement. The diagnosis of endocarditis was confirmed microbiologically and histologically. The causative strain belonged to the hypermucoid K1 capsular genotype and possessed the rmpA gene. The genome sequence was deposited in GenBank under the accession number JAQZBZ000000000.

摘要

产超广谱β-内酰胺酶肺炎克雷伯菌(hypervirulent Klebsiella pneumoniae,hvKP)可引起多部位感染和脓肿。然而,hvKP 感染导致心内膜炎较为罕见。本文报道 1 例社区获得性肝脓肿和前列腺脓肿继发的肺炎克雷伯菌 native valve 感染性心内膜炎。患者发生乳头肌断裂,导致二尖瓣反流,并接受紧急二尖瓣置换术。心内膜炎的诊断通过微生物学和组织学得到确认。该致病菌株属于高黏液型 K1 荚膜基因型,携带 rmpA 基因。基因组序列已在 GenBank 中注册,登录号为 JAQZBZ000000000。

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