Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Henan Key Laboratory of magnetic resonance and brain function, Zhengzhou 450052, China.
Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
J Neuroradiol. 2024 May;51(3):281-289. doi: 10.1016/j.neurad.2023.09.005. Epub 2023 Sep 29.
To investigate neurovascular coupling dysfunction in high myopia (HM) patients.
A total of 37 HM patients and 36 healthy controls were included in this study. Degree centrality (DC), regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), and fractional ALFF (fALFF) maps were employed to represent neuronal activity. Cerebral blood perfusion was characterized by cerebral blood flow (CBF). The correlation coefficient was calculated to reflect the relationship between neuronal activity and cerebral blood perfusion. Pearson partial correlation analysis was utilized to evaluate the association between HM dysfunction and clinical indicators.
HM patients exhibited significant alterations in neurovascular coupling across 37 brain regions compared to healthy controls. The brain regions with marked changes varied among the four neurovascular coupling patterns, including the middle frontal gyrus, superior occipital gyrus, middle occipital gyrus, and fusiform gyrus. Additionally, the superior frontal gyrus orbital part, medial superior frontal gyrus, inferior occipital gyrus, and dorsolateral superior frontal gyrus displayed significant changes in three coupling patterns. In HM patients, the ReHo-CBF changes in the inferior frontal gyrus orbital part were positively correlated with best-corrected visual acuity (BCVA) and refractive diopter changes. Similarly, the ALFF-CBF changes in the inferior frontal gyrus orbital part showed a positive correlation with refractive diopter changes. ReHo-CBF and ALFF-CBF alterations in the paracentral lobule were positively correlated with BCVA and refractive diopter changes.
Our findings underscore the abnormal alterations in neurovascular coupling across multiple brain regions in HM patients. These results suggest that neurovascular dysfunction in HM patients may be associated with an aberrant visual regulation mechanism.
研究高度近视（HM）患者的神经血管耦合功能障碍。
本研究共纳入 37 例 HM 患者和 36 名健康对照者。采用度中心度（DC）、局部一致性（ReHo）、低频波动幅度（ALFF）和分数 ALFF（fALFF）图来表示神经元活动。脑血流用脑血流（CBF）来描述。计算相关系数以反映神经元活动与脑血流之间的关系。采用 Pearson 偏相关分析评估 HM 功能障碍与临床指标的相关性。
与健康对照组相比，HM 患者在 37 个脑区存在明显的神经血管耦合改变。四种神经血管耦合模式中，改变明显的脑区包括额中回、顶下小叶、中回和梭状回。此外，额上回眶部、额上回内侧部、枕下回和额上回背外侧部在三种耦合模式中也有显著变化。在 HM 患者中，额下回眶部的 ReHo-CBF 改变与最佳矫正视力（BCVA）和屈光度变化呈正相关。同样，额下回眶部的 ALFF-CBF 改变与屈光度变化呈正相关。旁中央小叶的 ReHo-CBF 和 ALFF-CBF 改变与 BCVA 和屈光度变化呈正相关。
我们的研究结果强调了 HM 患者多个脑区神经血管耦合异常改变。这些结果提示 HM 患者的神经血管功能障碍可能与异常的视觉调节机制有关。
