Yao Shuo, Qin Ludan, Ma Li, Zhang Xiaoran, Jiang He, Zhang Jiajia, Zhou Chuanjian, Wu Junling
Department of Prosthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan 250012, China.
Research Institute of Polymer Materials, School of Materials Science and Engineering, Shandong University, Jinan 250061, China.
Dent Mater. 2023 Nov;39(11):1040-1050. doi: 10.1016/j.dental.2023.09.009. Epub 2023 Sep 29.
Dental resin composites have been the most popular materials for repairing tooth decay in recent years. However, secondary caries and bulk fracture are the major hurdles that affect the lifetime of dental resin composites. This current study synthesized a novel antimicrobial and self-healing dental resin containing nanoparticle-modified self-healing microcapsules to combat secondary caries and restoration fracture.
Multifunctional dental resins containing 0-20% nanoparticle-modified self-healing microcapsules were prepared. The water contact angle, antimicrobial properties, mechanical properties, cell toxicity, and self-healing capability of the dental resins were tested.
A novel multifunctional dental resin was synthesized. When the microcapsule mass fraction was 10%, the resin presented a strong bacteriostasis rate (80.3%) and excellent self-healing efficiency (66.1%), while the hydrophilicity, mechanical properties, and cell toxicity were not affected.
The novel antimicrobial self-healing dental resin is a promising candidate for use in clinical practice, which provides a simple and highly efficient strategy to combat secondary caries and restoration fracture. This novel dental resin also gives the inspiration to prolong the service life of dental restorations.
牙科树脂复合材料是近年来修复龋齿最常用的材料。然而，继发龋和大块断裂是影响牙科树脂复合材料使用寿命的主要障碍。本研究合成了一种新型抗菌自修复牙科树脂，其含有纳米颗粒改性的自修复微胶囊，以对抗继发龋和修复体断裂。
制备了含有0-20%纳米颗粒改性自修复微胶囊的多功能牙科树脂。测试了牙科树脂的水接触角、抗菌性能、力学性能、细胞毒性和自修复能力。
合成了一种新型多功能牙科树脂。当微胶囊质量分数为10%时，该树脂具有较强的抑菌率（80.3%）和优异的自修复效率（66.1%），同时亲水性、力学性能和细胞毒性不受影响。
新型抗菌自修复牙科树脂是一种很有前景的临床应用候选材料，它为对抗继发龋和修复体断裂提供了一种简单高效的策略。这种新型牙科树脂也为延长牙科修复体的使用寿命提供了启示。
