Alshuaibi M, Zugail A S, Lombion S, Beley S
Department of Urology, Clinique Turin, Groupe Almaviva Santé, Paris, France; Department of Urology, Faculty of Medicine, University of Ha'il, Ha'il, Saudi Arabia.
Department of Urology, Clinique Turin, Groupe Almaviva Santé, Paris, France; Department of Urology, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.
Fr J Urol. 2024 Jan;34(1):102526. doi: 10.1016/j.purol.2023.09.013. Epub 2023 Sep 28.
Intra-lesional injections of collagenase (Xiapex®) were the only non-invasive treatment option for Peyronie's disease (PD), until their withdrawal from the European market.
To evaluate the feasibility, efficacy, and safety of a combined treatment of percutaneous needle tunnelling (PNT) with penile modelling (PM) and the injection of platelet-rich plasma (PRP) under general anesthesia in the treatment of PD.
A prospective case series study included patients with PD in a stable phase who underwent this procedure between March 2020 and January 2023. The main outcome was an improvement in curvature.
Thirty-six patients underwent this novel approach for the treatment of PD. The pretreatment mean±standard deviation (SD) curvature degree was 57.5±20.61° (range 20-90°). After the protocol, the mean curvature degree was 40.86±25.13° (range 0-90°). The curvature angle improved significantly (P=0.0001), with a mean improvement difference of 16.85±14.81° (range 0-50°) and a mean improvement percentage of 47.7±40.29% (range 0-100%).
Our preliminary experience suggests that PNT and PRP injections with PM are effective and safe for the treatment of penile deformity of PD.
4: case series study.
在胶原酶（Xiapex®）从欧洲市场撤出之前，病灶内注射胶原酶是佩罗尼氏病（PD）唯一的非侵入性治疗选择。
评估在全身麻醉下经皮穿刺针隧道术（PNT）联合阴茎塑形（PM）及注射富血小板血浆（PRP）治疗PD的可行性、有效性和安全性。
一项前瞻性病例系列研究纳入了2020年3月至2023年1月期间接受该手术的处于稳定期的PD患者。主要结局是阴茎弯曲度的改善。
36例患者接受了这种治疗PD的新方法。治疗前平均±标准差（SD）弯曲度为57.5±20.61°（范围20 - 90°）。按照治疗方案治疗后，平均弯曲度为40.86±25.13°（范围0 - 90°）。弯曲角度有显著改善（P = 0.0001），平均改善差值为16.85±14.81°（范围0 - 50°），平均改善百分比为47.7±40.29%（范围0 - 100%）。
我们的初步经验表明，PNT联合PRP注射及PM治疗PD所致阴茎畸形是有效且安全的。
4级：病例系列研究。
