原发性干燥综合征患者血清胆红素水平：与间质性肺病的相关性。
Serum bilirubin levels in primary Sjögren's syndrome: an association with interstitial lung disease.
机构信息
Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Youjiang Medical University for Nationalities, No.18 Zhongshan Er Road, Baise, Guangxi, 533000, China.
Clinical Pathological Diagnosis and Research Centre, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
出版信息
BMC Pulm Med. 2023 Sep 30;23(1):366. doi: 10.1186/s12890-023-02672-5.
OBJECTIVE
We aimed to assess the association between serum bilirubin levels and interstitial lung disease (ILD) in patients with Primary Sjögren's syndrome (pSS).
MATERIALS AND METHODS
The retrospectively analysis included 89 consecutive patients with pSS, we collected the clinical materials of pSS patients from the electronic medical records, and all pSS patients were divide into pSS with ILD group and pSS without ILD group.
RESULTS
Serum bilirubin levels were significantly lower in pSS patients with ILD than those without ILD (p = 0.010). Serum bilirubin levels showed a significant negative correlation with erythrocyte sedimentation rate (ESR) (r = -0.321, p = 0.002) in patients with pSS. A multivariable logistic regression analysis confirmed that serum bilirubin presented an independent association with ILD in patients with pSS (OR = 0.841, 95%CI:0.728-0.972, p = 0.019).
CONCLUSION
Serum bilirubin is independently associated with ILD and therefore may be a promising marker of ILD in patients with pSS.
目的
评估原发性干燥综合征（pSS）患者血清胆红素水平与间质性肺病（ILD）的相关性。
材料与方法
回顾性分析了 89 例连续的 pSS 患者，我们从电子病历中收集了 pSS 患者的临床资料，并将所有 pSS 患者分为伴有 ILD 的 pSS 组和不伴有 ILD 的 pSS 组。
结果
伴有 ILD 的 pSS 患者的血清胆红素水平明显低于不伴有 ILD 的患者（p=0.010）。在 pSS 患者中，血清胆红素水平与红细胞沉降率（ESR）呈显著负相关（r=-0.321，p=0.002）。多变量逻辑回归分析证实，血清胆红素与 pSS 患者的 ILD 独立相关（OR=0.841，95%CI：0.728-0.972，p=0.019）。
结论
血清胆红素与 ILD 独立相关，因此可能是 pSS 患者 ILD 的一个有前途的标志物。
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