Rodrigo M R
Ann Acad Med Singap. 1986 Jul;15(3):315-9.
Thirty healthy Chinese between 17-36 years undergoing extraction of bilaterally similarly impacted third molars in two visits were randomly given nitrous oxide/oxygen inhalational sedation to supplement local anaesthesia or unsupplemented local anaesthesia for operation on one side and the alternative for the other. The majority in the study had never heard of inhalational sedation being available to supplement local anaesthesia, and when given a chance to experience this method, the majority preferred it to local anaesthesia alone. Supplementation of local anaesthesia with inhalational sedation produced patients who were more relaxed. With both methods, the operating conditions were assessed to be good, with good patient co-operation. Inhalational sedation with nitrous oxide/oxygen had no significant effect on vital signs, intraoperative or post operative adverse effects and patients were street fit within ten minutes of ending sedation.
30名年龄在17至36岁之间的健康中国受试者分两次接受双侧相似阻生第三磨牙拔除术，他们被随机给予氧化亚氮/氧气吸入镇静以辅助局部麻醉，或仅接受局部麻醉用于一侧手术，另一侧则采用另一种方法。研究中的大多数人从未听说过吸入镇静可用于辅助局部麻醉，当有机会体验这种方法时，大多数人更喜欢它而不是单纯的局部麻醉。吸入镇静辅助局部麻醉使患者更加放松。两种方法的手术条件评估均良好，患者配合度高。氧化亚氮/氧气吸入镇静对生命体征、术中或术后不良反应均无显著影响，且患者在镇静结束后十分钟内即可恢复正常活动。
