Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Health Sciences School & Medical Center, Universidad Internacional La Rioja (UNIR), Madrid, Spain.
Clin Liver Dis. 2023 Nov;27(4):955-972. doi: 10.1016/j.cld.2023.05.010. Epub 2023 Jul 1.
Hepatitis delta virus (HDV) only infects patients with hepatitis B virus (HBV) due to its reliance on HBV surface proteins to form its envelope. With shared routes of transmission, HDV coinfection is estimated to occur in 15% of patients with HIV and HBV. However, HDV is often underdiagnosed and may be missed particularly in people living with HIV (PLWH) who are already on antiretroviral therapy with anti-HBV activity and coincidental HBV suppression. At the same time, HDV causes the most severe form of chronic viral hepatitis and leads to faster progression of liver disease and hepatocellular carcinoma. Thus, increased recognition and effective treatment are paramount, and as novel treatment options approach global markets, the study of their efficacy in PLWH should be pursued.
丁型肝炎病毒（HDV）仅能感染乙型肝炎病毒（HBV）患者，这是因为它依赖 HBV 表面蛋白来形成其包膜。由于具有共同的传播途径，估计在合并 HIV 和 HBV 感染的患者中，有 15%会合并 HDV 感染。然而，HDV 常常诊断不足，特别是在已经接受具有抗 HBV 活性的抗逆转录病毒治疗且碰巧发生 HBV 抑制的 HIV 感染者（PLWH）中，HDV 可能会被漏诊。同时，HDV 可引起最严重的慢性病毒性肝炎，并导致肝病和肝细胞癌更快进展。因此，提高认识和有效治疗至关重要，随着新型治疗方案进入全球市场，应研究其在 PLWH 中的疗效。
