Department of Obstetrics and Gynaecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Endokrynol Pol. 2023;74(5):520-527. doi: 10.5603/ep.93291. Epub 2023 Oct 2.
There have been many studies assessing whether abnormal metabolic and hormone levels among women with polycystic ovary syndrome (PCOS) are associated with a greater risk of non-alcoholic fatty liver disease (NAFLD). However, previous studies repported no consistent outcomes. To provide a comprehensive evaluation regarding the role of PCOS in the risk of NAFLD, we updated the published literature and conducted this systemic review and meta-analysis.
Electronic databases (Web of Science and PubMed) were searched for literature up to October 2022. We used STATA 12.0 software to compute odds ratios (ORs) and 95% confidence intervals (CIs), to evaluate the association between PCOS and risk of NAFLD.
The study indicated that PCOS was significantly related to an elevated risk of NAFLD (OR = 2.93, 95% CI 2.38 to 3.62, I2 = 83.7%, p < 0.001). Meta-regression analysis showed that age and body mass index (BMI) were not responsible for heterogeneity across the studies (age: p = 0.096; BMI: p = 0.418). Sensitivity analysis indicated no alteration in the direction of effect when any study was eliminated. Begg's test, Egger's test, Begg's test, and funnel plot indicated a significant risk of publication bias (Egger's test: p = 0.028; Begg's test: p < 0.001).
This meta-analysis reported that PCOS was associated with an elevated risk of NAFLD. Early proper detection of NAFLD for PCOS women is essential. All patients with PCOS should undergo appropriate diagnostics for early detection of fatty liver and fibrosis.
有许多研究评估多囊卵巢综合征（PCOS）女性异常的代谢和激素水平是否与非酒精性脂肪性肝病（NAFLD）风险增加有关。然而，先前的研究报告没有一致的结果。为了全面评估 PCOS 在 NAFLD 风险中的作用，我们更新了已发表的文献，并进行了这项系统评价和荟萃分析。
检索了截至 2022 年 10 月的电子数据库（Web of Science 和 PubMed）中的文献。我们使用 STATA 12.0 软件计算比值比（OR）和 95%置信区间（CI），以评估 PCOS 与 NAFLD 风险之间的关联。
研究表明，PCOS 与 NAFLD 风险升高显著相关（OR=2.93，95%CI 2.38 至 3.62，I2=83.7%，p<0.001）。Meta 回归分析表明，年龄和体重指数（BMI）不是研究间异质性的原因（年龄：p=0.096；BMI：p=0.418）。敏感性分析表明，当任何一项研究被排除时，效应方向都没有改变。Begg 检验、Egger 检验、Beg 检验和漏斗图表明存在显著的发表偏倚风险（Egger 检验：p=0.028；Beg 检验：p<0.001）。
这项荟萃分析报告称，PCOS 与 NAFLD 风险增加有关。早期对 PCOS 女性的 NAFLD 进行适当检测至关重要。所有 PCOS 患者都应进行适当的诊断，以早期发现脂肪肝和纤维化。
