Centre for Public Health Research, Manbhum Ananda Ashram Nityananda Trust (MANT), Kolkata, West Bengal, India.
Department of Public Health Dentistry, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
JBI Evid Synth. 2024 Jan 1;22(1):97-105. doi: 10.11124/JBIES-23-00023.
The purpose of this systematic review is to assess the available economic evidence of a decentralized care model compared to a centralized model for treating multi-drug-resistant tuberculosis (MDR-TB) in low- and middle-income countries (LMICs).
Diseases that affect physiological health create a burden on human livelihoods and the economy. There is a lack of studies examining the economic evaluation of MDR-TB across different countries. A preliminary search identified no published or ongoing reviews on MDR-TB in LMICs.
Studies will be eligible if they include both patients receiving centralized care (ie, care provided by specialist centers through inpatient or outpatient services) and patients receiving decentralized care (ie, care provided by grassroots community workers in peripheral facilities or in the patients' residence) for MDR-TB in LMICs. Eligible studies will report economic evaluations of treatment for MDR-TB.
A preliminary search of MEDLINE (PubMed) was undertaken using MeSH terms, such as MDR-TB, economic evaluation, therapeutics, LMICs . Two reviewers will independently screen the titles, abstracts, and full text against the inclusion criteria. Disagreements will be resolved through discussion or with a third reviewer. The JBI checklist for economic evaluations will be utilized to evaluate the methodological quality. Data will be extracted using a modified JBI data extraction form for economic evaluations. The Dominance Ranking Matrix, developed by JBI for economic evaluations, will be used to summarize and compare the results of different types of economic evaluations (cost-effectiveness, cost-benefit analysis, cost-utility analysis, or cost-minimization analysis). Cost per quality-adjusted life year gained and cost per disability-adjusted life year averted will be measures for economic evaluation. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach will be used to assess the certainty of economic evidence.
PROSPERO CRD42022368696.
本系统评价旨在评估与集中式模型相比，在中低收入国家（LMICs）治疗耐多药结核病（MDR-TB）的分散式护理模式的现有经济证据。
影响生理健康的疾病给人类生计和经济带来负担。缺乏研究来检查不同国家的 MDR-TB 的经济评估。初步搜索未发现关于 LMICs 中 MDR-TB 的已发表或正在进行的综述。
如果研究包括接受集中护理（即通过住院或门诊服务由专科中心提供的护理）和接受分散护理（即由基层社区工作者在周边设施或患者住所提供的护理）的患者，这些研究将符合条件耐多药结核病（MDR-TB）在中低收入国家。合格的研究将报告 MDR-TB 治疗的经济评估。
使用 MeSH 术语（例如 MDR-TB、经济评价、治疗学、LMICs）对 MEDLINE（PubMed）进行初步搜索。两名审查员将独立筛选标题、摘要和全文，以符合纳入标准。通过讨论或第三位审查员解决分歧。将使用 JBI 经济评估检查表评估方法学质量。将使用 JBI 经济评估修改后的数据提取表提取数据。JBI 为经济评估开发的优势排名矩阵将用于总结和比较不同类型经济评估（成本效益分析、成本效益分析、成本效用分析或成本最小化分析）的结果。质量调整生命年获得成本和残疾调整生命年避免成本将作为经济评估的衡量标准。将使用推荐评估、开发和评估（GRADE）方法来评估经济证据的确定性。
PROSPERO CRD42022368696。
