Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, People's Republic of China.
Biomater Sci. 2023 Oct 24;11(21):7018-7033. doi: 10.1039/d3bm01103h.
Cells, exosomes, and nucleic acids play crucial roles in biomedical engineering, holding substantial clinical potential. However, their utility is often hindered by various drawbacks, including cellular immunogenicity, and instability of exosomes and nucleic acids. In recent years, microneedle (MN) technology has revolutionized drug delivery by offering minimal invasiveness and remarkable versatility. MN has emerged as an ideal platform for the extraction, storage, and delivery of these biological components. This review presents a comprehensive overview of the historical progression and recent advances in the field of MN. Specifically, it highlights the current applications of cell-, exosome-, and nucleic acid-based MN systems, while presenting prevailing research challenges. Additionally, the review provides insights into the prospects of MN in this area, aiming to provide new ideas for researchers and facilitate the clinical translation of MN technology.
细胞、细胞外囊泡和核酸在生物医学工程中发挥着至关重要的作用，具有巨大的临床潜力。然而，它们的应用常常受到多种缺陷的限制，包括细胞免疫原性以及细胞外囊泡和核酸的不稳定性。近年来，微针（MN）技术通过提供最小的侵入性和显著的多功能性，彻底改变了药物输送。MN 已成为提取、储存和输送这些生物成分的理想平台。本综述全面介绍了 MN 领域的历史进展和最新进展。具体而言，它强调了基于细胞、细胞外囊泡和核酸的 MN 系统的当前应用，同时介绍了当前的研究挑战。此外，该综述还探讨了 MN 在这一领域的前景，旨在为研究人员提供新的思路，并促进 MN 技术的临床转化。
