Bayer Diana K
Department of Pediatrics, University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, USA.
Curr Opin Pediatr. 2023 Dec 1;35(6):686-691. doi: 10.1097/MOP.0000000000001293. Epub 2023 Sep 29.
Atopic dermatitis is a chronic, systemic disease with primary cutaneous clinical manifestations and is commonly attributed to an exaggerated Th2 inflammatory response. Recent research regarding risk factors, prevention, clinical features, and management of atopic dermatitis will be reviewed.
In the last decade, advances have been made in identifying the factors that either confer increased risk for or protection from atopic dermatitis and associated atopy. Progress has also been made in the clinical management of this disease. Promising biomarkers and therapeutically informative characteristics of this disease have been identified in young children with and without the presence of eczema, but much has yet to be elucidated. Progress has also been made in clarifying the advantages and disadvantages of respective medical managements, including but not limited to topical corticosteroids, topical calcineurin inhibitors, phototherapy, systemic immunosuppressants, and targeted immunotherapy. Given that medical management may show variable efficacy in a child, an optimized skin care regimen is of utmost importance as well.
Atopic dermatitis is a challenging, chronic systemic disease that incurs significant morbidity in affected children. Although management options have been somewhat disappointing in years past, promising results have been observed in recent advances in targeted immunotherapy.
特应性皮炎是一种慢性全身性疾病，主要表现为皮肤临床症状，通常归因于Th2炎症反应过度。本文将对特应性皮炎的危险因素、预防、临床特征及治疗的最新研究进行综述。
在过去十年中，在确定导致特应性皮炎及相关特应性疾病风险增加或具有保护作用的因素方面取得了进展。该疾病的临床管理也取得了进展。在有或没有湿疹的幼儿中，已经确定了有前景的生物标志物和具有治疗指导意义的特征，但仍有许多有待阐明。在明确各种治疗方法（包括但不限于外用糖皮质激素、外用钙调神经磷酸酶抑制剂、光疗、全身免疫抑制剂和靶向免疫治疗）的优缺点方面也取得了进展。鉴于治疗方法在儿童中可能显示出不同的疗效，优化的皮肤护理方案也至关重要。
特应性皮炎是一种具有挑战性的慢性全身性疾病，给患病儿童带来了严重的发病率。尽管过去几年的治疗选择有些令人失望，但在靶向免疫治疗的最新进展中观察到了有前景的结果。
