Suda Y, Izuno O
Gan To Kagaku Ryoho. 1986 Oct;13(11):3180-5.
By means of pancreatic and biliary duct drainage in two pancreato-duodenectomized patients, excretion of CDDP into pancreatic and hepatic bile was studied. CDDP was infused at a dose of 50 mg/m2 for 40-60 min. Platinum was determined by the flameless atomic absorption spectrometric method. CDDP was excreted into pancreatic juice in the form of filterable platinum over a short duration and in a small amount. The excretion gradient into pancreatic juice was around 20%. Total output of CDDP in pancreatic juice was estimated to be 0.1% of administered platinum. Although no new observations on the urinary and biliary excretion of CDDP were obtained, it was noticed that platinum was excreted in filterable form in both urine and bile, and that the excretion gradients in each were approximately 300% and 35%, respectively, in the present study.
通过对两名接受胰十二指肠切除术的患者进行胰管和胆管引流，研究了顺铂（CDDP）在胰液和肝胆汁中的排泄情况。以50mg/m²的剂量输注CDDP 40 - 60分钟。采用无火焰原子吸收光谱法测定铂含量。CDDP在短时间内以可过滤铂的形式少量排泄到胰液中。进入胰液的排泄梯度约为20%。胰液中CDDP的总排出量估计为给药铂量的0.1%。虽然未获得关于CDDP尿液和胆汁排泄的新观察结果，但注意到在本研究中铂以可过滤形式排泄到尿液和胆汁中，且各自的排泄梯度分别约为300%和35%。
