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老年患者术后认知功能恢复及术后认知并发症的预防

Postoperative cognitive recovery and prevention of postoperative cognitive complications in the elderly patient.

作者信息

Almuzayyen Hisham A, Chowdhury Tumul, Alghamdi Abdulkareem S

机构信息

Department of Anesthesiology, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.

King Fahad Hospital of University, Imam Abdulrahman Bin Faisal University, Khobar, Saudi Arabia.

出版信息

Saudi J Anaesth. 2023 Oct-Dec;17(4):550-556. doi: 10.4103/sja.sja_529_23. Epub 2023 Aug 18.

DOI:10.4103/sja.sja_529_23
PMID:37779573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10540994/
Abstract

Elderly patients undergoing surgery are at higher risk of life-altering and costly complications. This challenge is increasingly recognized with the growing geriatric surgical population. Advanced age and comorbid conditions, such as disability and frailty that often develop with age, are all independent risk factors of postoperative morbidity and mortality. A common factor in this age group is cognitive impairment, which poses a challenge for the patient and clinician in the perioperative setting. It affects the capacity for informed consent and limits optimization before surgery; furthermore, an existing impairment may progress in severity during the perioperative period, and new onset of signs of delirium or postoperative cognitive dysfunction may arise during postoperative recovery. In this article, we aim to review the current literature examining the latest definitions, diagnostic criteria, and preventive strategies that may ameliorate postoperative cognitive complications.

摘要

接受手术的老年患者面临改变生活且代价高昂的并发症的风险更高。随着老年外科手术人群的不断增加,这一挑战日益受到关注。高龄以及残疾和虚弱等常随年龄增长而出现的合并症,都是术后发病和死亡的独立危险因素。该年龄组的一个常见因素是认知障碍,这在围手术期给患者和临床医生都带来了挑战。它影响知情同意的能力,并限制手术前的优化;此外,现有的损伤可能在围手术期加重,并且在术后恢复期间可能出现谵妄或术后认知功能障碍的新症状。在本文中,我们旨在回顾当前研究最新定义、诊断标准以及可能改善术后认知并发症的预防策略的文献。

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本文引用的文献

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The impact of regional versus general anesthesia on postoperative neurocognitive outcomes in elderly patients undergoing hip fracture surgery: A systematic review and meta-analysis.区域麻醉与全身麻醉对老年髋部骨折手术患者术后神经认知结局的影响:系统评价和荟萃分析。
Int J Surg. 2022 Sep;105:106854. doi: 10.1016/j.ijsu.2022.106854. Epub 2022 Aug 27.
2
Effects of inhalation and propofol anaesthesia on postoperative cognitive dysfunction in elderly noncardiac surgical patients: A systematic review and meta-analysis.吸入麻醉和异丙酚麻醉对老年非心脏手术患者术后认知功能障碍的影响:系统评价和荟萃分析。
Medicine (Baltimore). 2021 Oct 29;100(43):e27668. doi: 10.1097/MD.0000000000027668.
3
Dexmedetomidine Inhibits Neuroinflammation by Altering Microglial M1/M2 Polarization Through MAPK/ERK Pathway.右美托咪定通过 MAPK/ERK 通路改变小胶质细胞 M1/M2 极化抑制神经炎症。
Neurochem Res. 2020 Feb;45(2):345-353. doi: 10.1007/s11064-019-02922-1. Epub 2019 Dec 10.
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Effects of dexamethasone on post-operative cognitive dysfunction and delirium in adults following general anaesthesia: a meta-analysis of randomised controlled trials.地塞米松对全麻后成年人术后认知功能障碍和谵妄的影响:一项随机对照试验的荟萃分析。
BMC Anesthesiol. 2019 Jun 29;19(1):113. doi: 10.1186/s12871-019-0783-x.
5
Effect of dexmedetomidine on postoperative cognitive dysfunction and inflammation in patients after general anaesthesia: A PRISMA-compliant systematic review and meta-analysis.右美托咪定对全身麻醉患者术后认知功能障碍和炎症的影响:一项遵循PRISMA标准的系统评价和荟萃分析。
Medicine (Baltimore). 2019 May;98(18):e15383. doi: 10.1097/MD.0000000000015383.
6
Effect of parecoxib in the treatment of postoperative cognitive dysfunction: A systematic review and meta-analysis.帕瑞昔布治疗术后认知功能障碍的效果:一项系统评价和荟萃分析。
Medicine (Baltimore). 2019 Jan;98(1):e13812. doi: 10.1097/MD.0000000000013812.
7
Recommendations for the Nomenclature of Cognitive Change Associated with Anaesthesia and Surgery-2018.《麻醉和手术相关认知功能变化命名的建议-2018》
Anesthesiology. 2018 Nov;129(5):872-879. doi: 10.1097/ALN.0000000000002334.
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Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery.非心脏手术老年患者术后认知结局:静脉麻醉维持与吸入麻醉维持的比较
Cochrane Database Syst Rev. 2018 Aug 21;8(8):CD012317. doi: 10.1002/14651858.CD012317.pub2.
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Cochrane Database Syst Rev. 2018 May 15;5(5):CD011283. doi: 10.1002/14651858.CD011283.pub2.