慢性肉芽肿病合并家族性地中海热和早发性炎症性肠病患者的巨细胞病毒和爱泼斯坦-巴尔病毒合并感染：病例报告
Cytomegalovirus and Epstein-Barr Virus Co-infection in a Patient With Chronic Granulomatous Disease Co-existing With Familial Mediterranean Fever and Early-Onset Inflammatory Bowel Disease: A Case Report.
作者信息
Al Zu'bi Yazan O, Al Sharie Ahmed H, Al-Sweedan Suleimman, Al-Khatib Sohaib, Jaradat Saied A, Al Tamimi Eyad
机构信息
Department of Pediatrics, Faculty of Medicine, Jordan University of Science and Technology, Irbid, JOR.
Department of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, JOR.
出版信息
Cureus. 2023 Aug 30;15(8):e44360. doi: 10.7759/cureus.44360. eCollection 2023 Aug.
The association between primary immunodeficiencies and autoinflammatory disorders has been popularized over the past decade. In this report, we illustrated the co-infection of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in a three-year-old Jordanian male patient with an extremely rare variant of the gene (c.125C>G, p.Thr42Arg) associated with chronic granulomatous disease (CGD) coexisting with familial Mediterranean fever (FMF). CGD and FMF co-existence induced early-onset inflammatory bowel disease mainly resembling Crohn's disease.
在过去十年中，原发性免疫缺陷与自身炎症性疾病之间的关联已广为人知。在本报告中，我们阐述了一名三岁约旦男性患者巨细胞病毒（CMV）和爱泼斯坦-巴尔病毒（EBV）的合并感染情况，该患者患有与慢性肉芽肿病（CGD）相关的极为罕见的基因变体（c.125C>G，p.Thr42Arg），且同时患有家族性地中海热（FMF）。CGD和FMF共存引发了主要类似于克罗恩病的早发性炎症性肠病。
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