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原位心脏移植受者中的心尖肥厚型心肌病的罕见表现。

An Unusual Presentation of Apical Hypertrophic Cardiomyopathy in an Orthotopic Heart Transplant Recipient.

作者信息

Molina-Lopez Victor H, Engel-Rodriguez Andrew, Diaz-Rodriguez Porfirio E, Vicenty-Rivera Sonia

机构信息

Cardiology, Veterans Affairs Medical Center, San Juan, PRI.

Internal Medicine, Veterans Affairs Medical Center, San Juan, PRI.

出版信息

Cureus. 2023 Aug 29;15(8):e44344. doi: 10.7759/cureus.44344. eCollection 2023 Aug.

DOI:10.7759/cureus.44344
PMID:37779770
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10539037/
Abstract

In this case study, we present the evaluation of an orthotopic heart transplant (OHT) patient who presented with persistent shortness of breath and dizziness upon standing. The investigation uncovered the presence of progressive hypertrophic cardiomyopathy (HCM) in the transplanted heart, a condition first detected 11 years after the transplantation. Utilizing echocardiography with global longitudinal strain (GLS), we determined that the HCM likely originated from genetic predominance inherited from the heart donor rather than hypertensive disease. This finding highlights the significance of genetic factors in post-transplant complications and warrants further investigation into the long-term effects of heart transplantation on recipient health.

摘要

在本病例研究中，我们展示了对一名原位心脏移植（OHT）患者的评估，该患者站立时出现持续气短和头晕症状。调查发现移植心脏存在进行性肥厚型心肌病（HCM），这一情况在移植后11年首次被检测到。通过使用带有整体纵向应变（GLS）的超声心动图，我们确定HCM可能源于从心脏供体遗传的基因优势，而非高血压疾病。这一发现凸显了遗传因素在移植后并发症中的重要性，并值得进一步研究心脏移植对受者健康的长期影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dacc/10539037/ef0a97fcf25f/cureus-0015-00000044344-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dacc/10539037/747c3f709fff/cureus-0015-00000044344-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dacc/10539037/2d547a92db76/cureus-0015-00000044344-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dacc/10539037/a36e859889ee/cureus-0015-00000044344-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dacc/10539037/ef0a97fcf25f/cureus-0015-00000044344-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dacc/10539037/747c3f709fff/cureus-0015-00000044344-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dacc/10539037/2d547a92db76/cureus-0015-00000044344-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dacc/10539037/a36e859889ee/cureus-0015-00000044344-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dacc/10539037/ef0a97fcf25f/cureus-0015-00000044344-i04.jpg

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本文引用的文献

1
Hypertrophic Cardiomyopathy After Heart Transplantation: A Single-Center Case Series.心脏移植术后肥厚型心肌病：单中心病例系列
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Apical Hypertrophic Cardiomyopathy: The Variant Less Known.心尖肥厚型心肌病：鲜为人知的变异型
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Left ventricular apical hypertrophy in a transplanted heart: a case report.移植心脏中的左心室心尖肥厚：病例报告。
BMC Cardiovasc Disord. 2019 Apr 3;19(1):81. doi: 10.1186/s12872-019-1069-4.
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Cardiol Res. 2017 Oct;8(5):265-268. doi: 10.14740/cr619w. Epub 2017 Oct 27.
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Heart. 2016 Aug 1;102(15):1215-20. doi: 10.1136/heartjnl-2015-309121. Epub 2016 Mar 11.
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Congenit Heart Dis. 2015 May-Jun;10(3):E139-45. doi: 10.1111/chd.12242. Epub 2014 Dec 14.
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