Kwei-Nsoro Robert, Ojemolon Pius E, Attar Bashar, Shaka Hafeez, Zarza-Gulino Patricia, Asare Michael, Annor Eugene N, Mba Benjamin
Internal Medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA.
Gastroenterology and Hepatology, RUSH (Rush University System for Health) University Medical Center, Chicago, USA.
Cureus. 2023 Aug 29;15(8):e44315. doi: 10.7759/cureus.44315. eCollection 2023 Aug.
Background Eosinophilic esophagitis (EoE) is a chronic antigen-mediated esophageal disease characterized by infiltration of the esophageal mucosa by eosinophils. The prevalence of EoE continues to rise worldwide. However, certain aspects of the epidemiology and pathogenesis remain unclear. Methods This study examined the hospitalization trends of EoE using an extensive inpatient database in the United States, the National (Nationwide) Inpatient Sample (NIS), to identify hospitalizations between 2010 and 2019. We assessed patient demographics as well as hospital-specific variables using the NIS. We obtained the prevalence rate of EoE for each year and used joinpoint regression analysis to obtain trends after adjusting the rate for age and gender. We also sought to characterize the outcomes of these hospitalizations by obtaining the mortality rate, length of stay (LOS), and total hospital charges (THC). Results Of 305 million hospitalizations included in the study, 33,878 were for EoE. The prevalence rate per 100,000 hospitalizations of EoE increased from 6.6 in 2010 to 15.5 in 2019. The annual percentage change obtained from the joinpoint regression analysis was 13.3% from 2010 to 2014 and 7.2% from 2014 to 2019. Most of the hospitalizations were among the male gender and young adults. Almost 95% of hospitalizations across the study period were seen in urban hospitals. We did not notice any significant trend in the mortality rates or length of stay over the study period. The THC increased significantly across the study period. Conclusion There has been an upward trend in the average prevalence rate of EoE over the decade from 2010 to 2019 which almost parallels that of inflammatory bowel disease. This represents a significant burden of disease for a condition that was initially recognized in the late 20th century.
背景 嗜酸性食管炎（EoE）是一种慢性抗原介导的食管疾病，其特征是嗜酸性粒细胞浸润食管黏膜。EoE在全球范围内的患病率持续上升。然而，其流行病学和发病机制的某些方面仍不清楚。方法 本研究利用美国一个广泛的住院患者数据库——国家（全国）住院患者样本（NIS），研究EoE的住院趋势，以确定2010年至2019年期间的住院情况。我们使用NIS评估患者人口统计学以及医院特定变量。我们得出每年EoE的患病率，并使用连接点回归分析在调整年龄和性别率后得出趋势。我们还试图通过获取死亡率、住院时间（LOS）和总住院费用（THC）来描述这些住院治疗的结果。结果 在纳入研究的3.05亿次住院治疗中，33878次是因EoE。EoE每10万次住院治疗的患病率从2010年的6.6上升到2019年的15.5。连接点回归分析得出的年变化百分比在2010年至2014年为13.3%，在2014年至2019年为7.2%。大多数住院患者为男性和年轻人。在整个研究期间，几乎95%的住院患者出现在城市医院。在研究期间，我们没有注意到死亡率或住院时间有任何显著趋势。THC在整个研究期间显著增加。结论 从2010年到2019年的十年间，EoE的平均患病率呈上升趋势，这几乎与炎症性肠病的趋势平行。对于一种在20世纪后期才首次被认识的疾病来说，这代表了巨大的疾病负担。
