Stryckers Marijke, Van Oevelen Stefaan, Koshy Priyanka, Sprangers Ben, Van Craenenbroeck Amaryllis H
Department of Nephrology, H. Hart-Ziekenhuis, Lier, Belgium.
Department of Pathology, University Hospitals Leuven, Leuven, Belgium.
Clin Kidney J. 2023 Jul 6;16(10):1701-1702. doi: 10.1093/ckj/sfad161. eCollection 2023 Oct.
We report a case of a 38-year-old man who developed a nephrotic syndrome shortly after the start of guselkumab for the treatment of plaque psoriasis. Renal biopsy showed focal segmental glomerulosclerosis (FSGS). The clinical course of our case is highly suspect for drug-induced FSGS since the nephrotic syndrome resolved after cessation of the drug without relapse (2 years of follow-up). To the best of our knowledge, this is the first case describing FSGS lesions associated with the use of an interleukin-23 inhibitor.
我们报告了一例38岁男性病例，该患者在开始使用古塞库单抗治疗斑块状银屑病后不久出现了肾病综合征。肾活检显示为局灶节段性肾小球硬化（FSGS）。鉴于在停药后肾病综合征得到缓解且未复发（随访2年），我们病例的临床过程高度怀疑为药物性FSGS。据我们所知，这是第一例描述与使用白细胞介素-23抑制剂相关的FSGS病变的病例。
