Dong Yushan, Chen Jingyu, Sun Heng, Chen Yuhan, Jiao Yan, Gu Weikuan, Chen Hong, Liu Songjiang
Graduate School of Heilongjiang University of Chinese Medicine, No. 24, Heping Road, Xiangfang District, Harbin, Heilongjiang, China, 150040.
Department of Chinese Medicine Internal Medicine, Xiyuan Hospital, China Academy of Chinese Medical Sciences, No. 1, Xiyuan Playground, Haidian District, Beijing, 100091.
J Cancer. 2023 Sep 4;14(14):2720-2725. doi: 10.7150/jca.87719. eCollection 2023.
Colorectal cancer is a common clinical malignant tumor of the digestive tract, and intestinal flora has played an important role in the development of colorectal cancer. Bifidobacteria, as one of the main dominant florae in intestinal tract, can inhibit the occurrence and development of colorectal cancer through various mechanisms. Recent studies have shown that traditional Chinese medicine can regulate the abundance of bifidobacteria in intestinal tract and exhibit anti-tumor effects on colorectal cancer. Detailed investigations have revealed that the mechanisms of bifidobacteria in the treatment of colorectal cancer involve three aspects: the production of short-chain fatty acids, the regulation of the body's immunity, and the regulation of cell apoptosis and differentiation. In this review, we provide an updated summary of recent advances in our understanding of the mechanisms by which traditional Chinese medicine regulate intestinal flora to inhibit colorectal cancer development and metastasis.
结直肠癌是临床常见的消化道恶性肿瘤，肠道菌群在结直肠癌的发生发展中发挥着重要作用。双歧杆菌作为肠道内主要的优势菌群之一，可通过多种机制抑制结直肠癌的发生发展。近年来的研究表明，中药可调节肠道内双歧杆菌的丰度，并对结直肠癌发挥抗肿瘤作用。详细研究发现，双歧杆菌治疗结直肠癌的机制涉及三个方面：产生短链脂肪酸、调节机体免疫以及调节细胞凋亡和分化。在本综述中，我们对中药调节肠道菌群以抑制结直肠癌发生发展和转移的机制的最新研究进展进行了更新总结。
