Department of Medical Cell Biology, Zunyi Medical University, Zunyi, China.
Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Front Cell Infect Microbiol. 2022 Apr 28;12:863779. doi: 10.3389/fcimb.2022.863779. eCollection 2022.
The effect of a drug on the intestinal flora and the intestinal barrier is an important evaluation index for drug safety and efficacy. Chemical synthetic drugs are widely used due to their advantages of fast efficacy and low doses, but they are prone to cause drug resistance and inhibit proton pumps, which may harm intestinal health. Traditional Chinese medicine (TCM) has been applied clinically for thousands of years, and how TCMs regulate intestinal health to achieve their effects of disease treatment has become a hot research topic that needs to be resolved. This paper reviews the recent research on the effects of TCMs on intestinal microorganisms and the intestinal mucosal barrier after entering the intestine, discusses the interaction mechanisms between TCMs and intestinal flora, and details the repair effect of TCMs on the intestinal mucosal barrier to provide a reference for the development, utilization, and modernization of TCM.
药物对肠道菌群和肠道屏障的影响是药物安全性和疗效的重要评价指标。化学合成药物由于起效快、剂量低等优点而被广泛应用，但容易产生耐药性，抑制质子泵，从而可能损害肠道健康。中药（TCM）在临床上已经应用了几千年，TCM 如何调节肠道健康以达到治疗疾病的效果已成为一个亟待解决的热门研究课题。本文综述了 TCM 进入肠道后对肠道微生物和肠道黏膜屏障的影响，探讨了 TCM 与肠道菌群的相互作用机制，并详细阐述了 TCM 对肠道黏膜屏障的修复作用，为 TCM 的开发、利用和现代化提供参考。
