Zhu Jiayi, Liu Yan, Zhang Zhao, Yang Xili, Qiu Feng
Department of Cardiology, The First People's Hospital of Foshan, No. 81 Lingnan RD, Foshan 528000, China.
Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Sun Yat-Sen University, Shenzhen 518107, China.
ACS Omega. 2023 Sep 11;8(38):34557-34563. doi: 10.1021/acsomega.3c03234. eCollection 2023 Sep 26.
We have designed and synthesized two Ir(III) complexes ( and ) coordinated with an 8-sulfonamidoquinoline derivative ligand as photosensitizers, which exhibit strong red phosphorescence emission and a long phosphorescence lifetime. The Ir(III) complexes exhibit a high population of triplet states, which enable red phosphorescence and efficient singlet oxygen generation. and rapidly enter the cancer cells and accumulate in lysosomes, producing large amounts of intracellular singlet oxygen when exposed to light irradiation, eventually leading to cancer cell death, and the phototoxic indexes of complexes and against cancer cells are in the range of 76-228. Overall, our studies indicate that the synthesized Ir(III) complexes with quinoline ligands exhibit photosensitizing properties, effectively inducing cancer cell death when exposed to light. These promising results suggest their potential application in photodynamic therapy.
我们设计并合成了两种与8-磺酰胺基喹啉衍生物配体配位的铱（III）配合物（ 和 ）作为光敏剂，它们表现出强烈的红色磷光发射和较长的磷光寿命。铱（III）配合物表现出高的三重态布居数，这使得能够产生红色磷光并有效生成单线态氧。 和 迅速进入癌细胞并在溶酶体中积累，在光照下产生大量细胞内单线态氧，最终导致癌细胞死亡，配合物 和 对癌细胞的光毒性指数在76-228范围内。总体而言，我们的研究表明，合成的含喹啉配体的铱（III）配合物具有光敏特性，在光照下能有效诱导癌细胞死亡。这些有前景的结果表明它们在光动力疗法中的潜在应用。
