具有聚集诱导发光特性的铱(III)配合物在生物应用中的研究进展。
Ir(III) Complexes with AIE Characteristics for Biological Applications.
机构信息
Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.
Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun 130024, China.
出版信息
Biosensors (Basel). 2022 Dec 1;12(12):1104. doi: 10.3390/bios12121104.
Both biological process detection and disease diagnosis on the basis of luminescence technology can provide comprehensive insights into the mechanisms of life and disease pathogenesis and also accurately guide therapeutics. As a family of prominent luminescent materials, Ir(III) complexes with aggregation-induced emission (AIE) tendency have been recently explored at a tremendous pace for biological applications, by virtue of their various distinct advantages, such as great stability in biological media, excellent fluorescence properties and distinctive photosensitizing features. Significant breakthroughs of AIE-active Ir(III) complexes have been achieved in the past few years and great progress has been witnessed in the construction of novel AIE-active Ir(III) complexes and their applications in organelle-specific targeting imaging, multiphoton imaging, biomarker-responsive bioimaging, as well as theranostics. This review systematically summarizes the basic concepts, seminal studies, recent trends and perspectives in this area.
基于发光技术的生物过程检测和疾病诊断可以提供对生命机制和疾病发病机制的全面了解，也可以准确指导治疗。作为一类突出的发光材料，具有聚集诱导发光（AIE）倾向的 Ir（III）配合物最近在生物应用方面得到了飞速的探索，这得益于它们具有各种独特的优势，如在生物介质中具有极好的稳定性、优异的荧光性质和独特的光致敏化特性。在过去的几年中，AIE 活性 Ir（III）配合物取得了重大突破，在新型 AIE 活性 Ir（III）配合物的构建及其在细胞器特异性靶向成像、多光子成像、生物标志物响应生物成像以及治疗学方面的应用方面取得了重大进展。本文系统地总结了该领域的基本概念、开创性研究、最新趋势和展望。
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