Panner Selvam Manesh Kumar, Kanagaraj Vijayrani, Kathaperumal Kumanan, Nissly Ruth H, Daly Janet M, Kuchipudi Suresh V
Department of Animal Biotechnology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai, India.
Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, USA.
Virusdisease. 2023 Sep;34(3):402-409. doi: 10.1007/s13337-023-00833-y. Epub 2023 Aug 9.
Newcastle disease (ND) affects a few hundred avian species including chicken and several species of domestic and wild birds. The clinical outcome of Newcastle disease virus (NDV) infection ranges from mild to severe fatal disease depending on the NDV pathotype and the host species involved. Japanese quails serve as natural reservoirs of NDV and play important role in NDV epidemiology. While infection of chicken with velogenic NDV results in severe often fatal illness, the same infection in Japanese quails results in inapparent infection. The molecular basis of this contrasting clinical outcomes of NDV infection is not yet clearly known. We compared global gene expression in spleen of chicken and Japanese quails infected with lentogenic and velogenic NDVs. We found contrasting regulation of key genes associated with NF-κB pathway and T-cell activation between chicken and Japanese quails. Our data suggests association of NDV resistance in Japanese quails to activation of NF-κB pathway and T cell proliferation.
The online version contains supplementary material available at 10.1007/s13337-023-00833-y.
新城疫（ND）影响数百种鸟类，包括鸡以及几种家养和野生鸟类。新城疫病毒（NDV）感染的临床结果从轻度到严重致命疾病不等，这取决于NDV的致病型和所涉及的宿主物种。日本鹌鹑是NDV的天然宿主，在NDV流行病学中发挥重要作用。虽然强毒力NDV感染鸡会导致严重的、通常致命的疾病，但相同的感染在日本鹌鹑中则导致隐性感染。NDV感染这种截然不同的临床结果的分子基础尚不清楚。我们比较了感染弱毒力和强毒力NDV的鸡和日本鹌鹑脾脏中的全局基因表达。我们发现鸡和日本鹌鹑之间与NF-κB途径和T细胞活化相关的关键基因存在相反的调控。我们的数据表明日本鹌鹑对NDV的抗性与NF-κB途径的激活和T细胞增殖有关。
在线版本包含可在10.1007/s13337-023-00833-y获取的补充材料。
