Northeastern University, Boston, MA, United States.
The University of Queensland, Brisbane, Australia.
Osteoarthritis Cartilage. 2024 Jan;32(1):93-97. doi: 10.1016/j.joca.2023.09.008. Epub 2023 Sep 30.
Anterior knee pain (AKP) is associated with patellofemoral osteoarthritis (PFOA), but longitudinal studies are lacking. If AKP precedes PFOA, it may create an opportunity to identify and intervene earlier in the disease process. The purpose of this study was to examine the longitudinal relation of AKP to worsening patellofemoral (PF) cartilage over two years.
Participants were recruited from the Multicenter Osteoarthritis Study, a longitudinal study of individuals with or at risk for knee osteoarthritis (OA). Exclusion criteria included bilateral knee replacements, arthritis other than OA, and radiographic PFOA. At baseline, participants completed a knee pain map questionnaire and underwent knee magnetic resonance imaging (MRI). Imaging was repeated at 2-year follow-up. Exposure was presence of frequent AKP. Outcome was worsening cartilage damage in the PF joint defined as increase in MRI Osteoarthritis Knee Score from baseline to 2 years. Log-binomial models were used to calculate risk ratios (RR).
One knee from 1083 participants (age 56.7 ± 6.6 years; body mass index 28.0 ± 4.9 kg/m) was included. Frequent AKP and frequent isolated AKP were present at baseline in 14.5% and 3.6%, respectively. Frequent AKP was associated with an increased risk (RR: 1.78, 95% confidence interval: 1.21, 2.62) of 2-year worsening cartilage damage in the lateral PF compartment. No association was found between frequent AKP and worsening in the medial PF joint.
Frequent AKP at baseline was associated with worsening cartilage damage in the lateral PF joint over 2 years.
膝关节前痛（AKP）与髌股关节骨关节炎（PFOA）有关，但缺乏纵向研究。如果 AKP 先于 PFOA，则可能有机会在疾病进程中更早地识别和干预。本研究旨在探讨 AKP 与两年内髌股（PF）软骨恶化的纵向关系。
参与者是从多中心骨关节炎研究中招募的，这是一项针对有或有膝关节骨关节炎（OA）风险的个体的纵向研究。排除标准包括双侧膝关节置换、非 OA 关节炎和放射学 PFOA。在基线时，参与者完成了膝关节疼痛图问卷，并接受了膝关节磁共振成像（MRI）检查。在 2 年随访时进行了影像学复查。暴露是存在频繁的 AKP。结局是 PF 关节软骨损伤恶化，定义为 MRI 骨关节炎膝关节评分从基线到 2 年的增加。使用对数二项式模型计算风险比（RR）。
纳入了 1083 名参与者中 1 只膝关节（年龄 56.7±6.6 岁；体重指数 28.0±4.9kg/m）。基线时有 14.5%和 3.6%的人存在频繁 AKP 和频繁孤立性 AKP。频繁 AKP 与 2 年时外侧 PF 间隔软骨恶化的风险增加（RR：1.78，95%置信区间：1.21，2.62）相关。频繁 AKP 与内侧 PF 关节的恶化之间没有关联。
基线时频繁的 AKP 与 2 年内外侧 PF 关节软骨的恶化有关。
