Brandis H, Andries L
Zentralbl Bakteriol Orig A. 1979 Apr;243(2-3):207-15.
Among 262 strains of Salmonella typhi from an epidemic outbreak of typhoid fever in Baden-Württemberg in 1974 2 strains were isolated which were tetracyclin resistant and showed no reactions with the Vi testphages T, D6 and VII whilst all other strains belonged to lysotype A, subtype Tananarive. It turned out that the Tc resistance in both strains was caused by a fi- R plasmid which could be transfered to other S. typhi strains, to E. coli K12, S. paratyphi B, S. java and S. typhi-murium as well as from Tc resistant E. coli K12 back to S. typhi. The Tc R plasmid introduced in S. typhi, lysotype A, caused specific restrictions of typing phages T, D6 and VII. Also, the transfer of the plasmids to strains of S. paratyphi B and S. typhi-murium resulted in restrictions of a number of typing phages. Both plasmids had identical patterns of restriction. In this pattern the Tc R plasmid differed from those described in the literature.
在1974年巴登 - 符腾堡州伤寒热流行爆发的262株伤寒沙门氏菌中，分离出2株对四环素耐药，且对Vi试验噬菌体T、D6和VII无反应，而所有其他菌株属于溶菌型A，塔纳纳里夫亚型。结果表明，这两株菌的四环素耐药性是由一种Fi - R质粒引起的，该质粒可转移到其他伤寒沙门氏菌菌株、大肠杆菌K12、副伤寒沙门氏菌B、爪哇沙门氏菌和鼠伤寒沙门氏菌，也可从四环素耐药的大肠杆菌K12转移回伤寒沙门氏菌。引入溶菌型A伤寒沙门氏菌的四环素耐药质粒导致分型噬菌体T、D6和VII的特异性限制。此外，质粒转移到副伤寒沙门氏菌B和鼠伤寒沙门氏菌菌株也导致一些分型噬菌体的限制。两种质粒具有相同的限制模式。在这种模式下，四环素耐药质粒与文献中描述的质粒不同。
