Bruijnzeel P L, van den Berg W, Hamelink M L, van den Bogaard W, Houben L A, Kreukniet J
Ann Allergy. 1979 Aug;43(2):105-9.
Development of beta-receptor desensitization in leucocytes of asthmatics and normals during oral therapy with terbutaline was established by means of in vitro stimulation with terbutaline and isoproterenol. This desensitization disappeared about one week after oral therapy was discontinued. In addition no difference in stimulation pattern, measured as increase in intracellular c-AMP content, was determined between asthmatics and normals when both were not receiving therapy. Even when the asthmatics showed strong bronchial hyperreactivity no difference was found. These results do not support the beta-adrenergic blockade hypothesis of Szentivanyi.
通过用特布他林和异丙肾上腺素进行体外刺激，确定了哮喘患者和正常人在口服特布他林治疗期间白细胞中β受体脱敏的发展情况。这种脱敏在停止口服治疗约一周后消失。此外，在未接受治疗时，哮喘患者和正常人之间在以细胞内c-AMP含量增加来衡量的刺激模式上没有差异。即使哮喘患者表现出强烈的支气管高反应性，也未发现差异。这些结果不支持森蒂瓦尼的β-肾上腺素能阻滞假说。
