Kahn E, Montès E, Bertin F, Contesso G, Di Paola R
Anal Quant Cytol Histol. 1986 Sep;8(3):259-62.
The possibly prognostic value of elastosis in breast carcinoma has usually been visually evaluated, using subjective gradings whose variability has led to contradictory conclusions. We used a Magiscan 2 automated image analyzer to perform objective measurements on elastosis on a set of 52 slides that were also subjectively evaluated. The wide range of parameters measurable by the automated system seemed likely to successfully deal with the lack of homogeneity of elastosis that causes problems in subjective evaluations. The homogeneity parameters (percentage distributions of elastosis in each slide) were processed by factorial analysis. On the plane defined by the first two factors, the principal components analysis produced a clustering of cases that was, on the whole, in concordance with the subjective evaluation.
乳腺癌中弹性组织变性的潜在预后价值通常是通过主观分级进行视觉评估的，这些分级的可变性导致了相互矛盾的结论。我们使用Magiscan 2自动图像分析仪对一组52张幻灯片上的弹性组织变性进行客观测量，这些幻灯片也经过了主观评估。自动系统可测量的广泛参数似乎有可能成功解决弹性组织变性缺乏同质性的问题，而这种同质性缺乏在主观评估中会导致问题。通过因子分析处理同质性参数（每张幻灯片中弹性组织变性的百分比分布）。在前两个因子定义的平面上，主成分分析产生了病例聚类，总体上与主观评估一致。
