给予乙醇或乙醛后大鼠血浆和肝脏中的氨基酸
Plasma and liver amino acids in rats after administration of ethanol or acetaldehyde.
作者信息
Farbiszewski R, Gabryel H, Palka J, Holownia A, Sokol A
出版信息
Biochem Med Metab Biol. 1986 Oct;36(2):239-43. doi: 10.1016/0885-4505(86)90131-3.
PMID:3778689
Abstract
The changes in the level and pattern of free amino acids in plasma and liver after ethanol or acetaldehyde intoxication has been investigated in rats. After administration of 30% (w/v) ethanol, 6 g kg-1, or 1.5% (w/v) acetaldehyde, 0.3 ml kg-1, for 4 weeks we found a decrease in plasma and liver branched-chain amino acids and an increase in plasma aromatic amino acids and methionine. The results are analogous to those found in studies of damaged liver.
摘要
已对大鼠乙醇或乙醛中毒后血浆和肝脏中游离氨基酸水平及模式的变化进行了研究。给予30%（w/v）乙醇6 g/kg或1.5%（w/v）乙醛0.3 ml/kg，持续4周后，我们发现血浆和肝脏中的支链氨基酸减少，血浆芳香族氨基酸和蛋氨酸增加。这些结果与在受损肝脏研究中发现的结果相似。
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