Mani Rishit, Gupta Amit, Gupta Sweety, Goyal Bela, Mishra Rahul, Tandon Amoli, Sharma Oshin, Rohilla Kusum K, Kishore Sanjeev, Dhar Puneet
Department of Surgery, All India Institute of Medical Science, Rishikesh, Uttarakhand, India.
Department of Radiation Oncology, All India Institute of Medical Science, Rishikesh, Uttarakhand, India.
J Cancer Res Ther. 2023 Jul-Sep;19(5):1279-1287. doi: 10.4103/jcrt.jcrt_1754_21.
Females having a large proportion of gallbladder carcinoma (GBC) and a higher incidence of gallstones pointed toward the role of sex hormones in GBC development. In this study, we evaluated the expression of Estrogen receptor (ER), Progesterone receptor (PR), and Her2/neu and their correlation with tumor markers and clinicopathological parameters in the GBC.
A total of 50 patients of GBC and 42 patients in control group undergoing surgery for other conditions were taken. The patient's biopsy sample's paraffin block was tested for ER, PR, and Her2/neu expression by immunohistochemistry.
ER and PR had no significant expression in GBC and control group, but Her2/neu had 16% expression in GBC, significantly associated with the degree of differentiation with 62.5% (n-5) being well-differentiated; 75% of Her2/neu positive were in stages III and IV. Her2/neu did not correlate with tumor markers despite expression.
Her2/neu amplification is a small step in validating that option so it could be included in the treatment and prognostication of GBC.
女性在胆囊癌（GBC）患者中占比很大，且胆结石发病率较高，这表明性激素在GBC发展过程中发挥了作用。在本研究中，我们评估了雌激素受体（ER）、孕激素受体（PR）和Her2/neu的表达情况，以及它们与GBC中肿瘤标志物和临床病理参数的相关性。
选取50例GBC患者以及42例因其他病症接受手术的对照组患者。通过免疫组织化学法检测患者活检样本石蜡块中的ER、PR和Her2/neu表达情况。
ER和PR在GBC组和对照组中均无明显表达，但Her2/neu在GBC组中有16%的表达，与分化程度显著相关，其中62.5%（n = 5）为高分化；75%的Her2/neu阳性患者处于III期和IV期。尽管有表达，但Her2/neu与肿瘤标志物无关。
Her2/neu扩增是验证该选项的一小步，因此它可纳入GBC的治疗和预后评估中。
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