Department of Oral Pathology, Sree Mookambika Institute of Dental Sciences, Kanniyakumar, Tamil Nadu, India.
J Cancer Res Ther. 2023 Jul-Sep;19(5):1450-1453. doi: 10.4103/jcrt.jcrt_77_21.
Spindle cell carcinoma (SpCC) is a rare variant of oral squamous cell carcinoma (SCC) with unique clinicopathological characteristics, a high recurrence rate, and metastatic potential. It will be truly devastating when it occurs as a second wave in a cancer survivor. Despite the multidisciplinary approach in the management of oral SCC, the incidence of second malignancies or multiple carcinomas has been constantly reporting in the literature. Although radiotherapy has saved the lives of countless cancer patients, its several serious late effects are well-documented in the literature, making it a double-edged sword. Radiation epidemiology studies revealed an increased risk of developing radiogenic second cancers after 5 or more years. The purpose of this article is to document a case of SpCC arising in a patient after a span of 5 years who was previously diagnosed and treated with radiotherapy for well-differentiated SCC.
梭形细胞癌（SpCC）是一种罕见的口腔鳞状细胞癌（SCC）变体，具有独特的临床病理特征、高复发率和转移潜能。当它作为癌症幸存者的第二波出现时，将会是真正毁灭性的。尽管在口腔 SCC 的管理中采用了多学科方法，但文献中仍不断有第二恶性肿瘤或多发性癌的报道。虽然放射治疗挽救了无数癌症患者的生命，但它的一些严重的晚期效应在文献中有详细记载，这使它成为一把双刃剑。放射流行病学研究表明，在 5 年或更长时间后，发生放射性第二癌症的风险增加。本文的目的是记录一例 SpCC 病例，该患者在 5 年前曾被诊断为分化良好的 SCC，并接受放射治疗。
